Negative-pressure wound dressing after kidney transplant
Official title: NEgative prEssure Wound Therapy in Renal Transplant - NEWER Trial
Run by Centro Hospitalar De São João, E.P.E. · NCT07065734 · Data updated 2026-11-12
This study tests whether using a negative-pressure wound dressing right after open kidney transplant reduces wound problems for adult transplant recipients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Centro Hospitalar De São João, E.P.E. Academic / other |
| Locations | 1 site (Porto) |
| Status | Recruiting |
| Started | January 1, 2023 |
| Main results expected | May 31, 2026 |
| Study ends | June 30, 2026 |
| Registry record updated | July 15, 2025 |
| Trial ID | NCT07065734 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Suitable candidates are adult patients undergoing open kidney transplant who are not pediatric, do not require planned reintervention within 90 days, are not allergic to NPWT components, and are not having an orthotopic transplant.
✕Probably not a fit
Patients who are pediatric, require early surgical reintervention, have allergies to NPWT materials, or have orthotopic transplants would not be expected to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, randomized Phase 4 trial enrolled adults undergoing open kidney transplant between January 2023 and August 2024 and assigned them to either intraoperative negative-pressure wound therapy (NPWT) with PICO (Smith & Nephew) at 80 mmHg for 7 days or to standard wound dressings. Pediatric patients, those needing surgical reintervention within 90 days, patients allergic to NPWT components, and orthotopic transplants were excluded. Wounds were evaluated at 7, 14, 30, and 90 days for dehiscence (classified as superficial or deep), infection using the ASEPSIS score, pain by visual analogue scale, quality of life by EQ-5D, and scar healing by POSAS at 30 and 90 days. The design compares short-term wound outcomes and patient-reported measures between the two dressing approaches.
Why it matters
Potential benefit: If successful, NPWT could lower wound infections and dehiscence and speed recovery after kidney transplant.
How similar studies have gone: Prophylactic NPWT has shown benefits in lowering wound complications in several surgical fields, but data specifically in kidney transplant patients are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients submitted to kidney transplant Exclusion Criteria: * Pediatric patients, those requiring surgical reinterventions within the first 90 days postoperative, patients allergic to NPWT components, orthotopic transplant
Where it's running
-
São João University Hospital
Porto, Portugal Recruiting
Study contacts
- Study coordinator: Alberto Silva, MD
- Email: u016845@chsj.min-saude.pt
- Phone: +351225512100
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.