Nebulized ketamine versus nebulized dexmedetomidine for pain control after endoscopic nasal surgery

Pre-emptive Analgesia Using Nebulized Ketamine Versus Nebulized Dexmedetomidine in Endoscopic Nasal Surgeries

This trial will test whether inhaled (nebulized) ketamine or inhaled dexmedetomidine provides better pain relief after endoscopic nasal surgery for adults aged 20 to 60.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 105 (estimated)
• Ages: 20 Years to 60 Years
• Sex: All
• Sponsor: Sohag University (Academic / other)
• Locations: 1 site (Sohag)
• Trial ID: NCT07056582 on ClinicalTrials.gov

What this trial studies

Participants scheduled for endoscopic nasal surgery receive a pre-emptive nebulized dose of ketamine, nebulized dexmedetomidine, or saline before anesthesia, and postoperative pain scores and analgesic consumption are recorded. The trial enrolls ASA I–II adults aged 20–60 with BMI 18–30 and excludes those with major organ disease, pregnancy, recent CNS depressant use, or hemodynamic instability. Pain is measured at standardized postoperative time points using validated pain scales, and vital signs are monitored for drug-related effects. The goal is to identify which nebulized agent gives better immediate postoperative analgesia and whether either reduces opioid requirements.

Who should consider this trial

Good fit: Adults 20–60 years old scheduled for endoscopic nasal surgery who are ASA physical status I–II with BMI between 18 and 30, not pregnant or breastfeeding, and without significant organ or psychiatric disease.

Not a fit: Patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women, those with drug allergies, recent CNS depressant or analgesic use, or unstable blood pressure/heart rate are unlikely to be eligible or to benefit.

Why it matters

Potential benefit: If successful, one of the nebulized drugs could offer better immediate pain relief after endoscopic nasal surgery and reduce the need for opioid painkillers.

How similar studies have performed: Smaller studies and case series have reported that nebulized ketamine or dexmedetomidine can reduce postoperative pain in airway and minor surgical settings, but direct head-to-head comparisons are limited.

Eligibility criteria

Inclusion Criteria:

* patients between the ages of 20 and 60,
* both sexes,
* American Society of Anesthesiologists physical status I to II
* BMI ≥18≤30 kg/m²

Exclusion Criteria:

* Patient refusal.
* patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women.
* patients with a history of allergies to any study drugs.
* patients who had used central nervous system depressants or analgesics within the previous 24 hours.
* patients with hypertension, hypotension, or bradycardia.

Where this trial is running

Sohag

• Sohag university hospital — Sohag, Egypt (Recruiting)

Study contacts

• Study coordinator: Ahmed T Abdelhameed, Resident

Conditions Nose Diseases