Nebulized ketamine versus nebulized dexmedetomidine for pain control after endoscopic nasal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants scheduled for endoscopic nasal surgery receive a pre-emptive nebulized dose of ketamine, nebulized dexmedetomidine, or saline before anesthesia, and postoperative pain scores and analgesic consumption are recorded. The trial enrolls ASA I–II adults aged 20–60 with BMI 18–30 and excludes those with major organ disease, pregnancy, recent CNS depressant use, or hemodynamic instability. Pain is measured at standardized postoperative time points using validated pain scales, and vital signs are monitored for drug-related effects. The goal is to identify which nebulized agent gives better immediate postoperative analgesia and whether either reduces opioid requirements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* patients between the ages of 20 and 60,
* both sexes,
* American Society of Anesthesiologists physical status I to II
* BMI ≥18≤30 kg/m²

Exclusion Criteria:

* Patient refusal.
* patients with advanced respiratory, renal, hepatic, neurological, or psychiatric disease, pregnant or nursing women.
* patients with a history of allergies to any study drugs.
* patients who had used central nervous system depressants or analgesics within the previous 24 hours.
* patients with hypertension, hypotension, or bradycardia.

Where it's running

• Sohag university hospital
  Sohag, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed T Abdelhameed, Resident
• Email: ahmedthanocloser460@gmail.com
• Phone: 01012833899

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.