Nebulised nitric oxide treatment for patients with non-cystic fibrosis bronchiectasis and Pseudomonas aeruginosa

Phase 1/2a Trial to Evaluate the Safety, Tolerability and Efficacy of Nebulised RESP30X Nitric Oxide Formulations in Non-Cystic Fibrosis Bronchiectasis (NCFB) Patients with Pseudomonas Aeruginosa (Pa) or Other Potentially Pathogenic Micro-organisms (PPMs)

This study is testing if a new nebulized treatment can help adults with non-cystic fibrosis bronchiectasis and high levels of Pseudomonas aeruginosa breathe better and manage their lung infections.

Quick facts

• Phase: Phase1; Phase2
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Thirty Respiratory Limited (Industry-sponsored)
• Locations: 1 site (Kyiv)
• Trial ID: NCT06663176 on ClinicalTrials.gov

What this trial studies

This clinical trial evaluates the safety, tolerability, pharmacokinetics, and efficacy of nebulised RESP30X formulations in adult patients with non-cystic fibrosis bronchiectasis who have high levels of Pseudomonas aeruginosa. The study is divided into two parts, with the first part focusing on a small group of patients receiving a single ascending dose of RESP303, followed by multiple daily dosing for 28 days. The second part will involve a larger group of participants who will be randomized to receive either RESP302 or RESP303, also for 28 days. The study aims to assess the potential benefits of these treatments in managing respiratory infections in this patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with a clinical history of bronchiectasis and confirmed high-titre Pseudomonas aeruginosa infections.

Not a fit: Patients without confirmed high-titre respiratory pathogens or those with other underlying respiratory conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could improve respiratory health and reduce infections in patients with non-cystic fibrosis bronchiectasis.

How similar studies have performed: While there have been studies on nitric oxide in other respiratory conditions, this specific approach in non-cystic fibrosis bronchiectasis is novel and has not been extensively tested.

Eligibility criteria

Inclusion Criteria:

* Provide written, informed consent prior to all study-related procedures and agree to undergo all study procedures.
* Aged between 18 and 75 years, inclusive.
* Clinical history of bronchiectasis affecting 1 or more lobes based on symptoms (cough, sputum productive and/or recurrent lower respiratory tract infections) as confirmed by historical CT scan and radiology report performed within the last 5 years.
* Confirmed high-titre respiratory PPMs (Part 1: Pa only) at screening ≥10\^5 CFU/mL (as determined by central laboratory microbiological cultures).
* Individuals of childbearing potential must agree to use protocol defined method(s) of contraception during the study and for at least 90-days after the last dose of IMP.
* Patients who can produce spontaneous sputum on a daily basis.
* Patients who are able to self-administer the SABA inhaler and study nebuliser for IMP administration effectively in the Investigator's opinion, following training.
* Patients appropriately vaccinated against influenza and pneumococcus at least 14-days prior to Day 1.

Exclusion Criteria:

* Currently receiving therapy with any inhaled antibiotic therapy. Patients who have previously received inhaled antibiotic therapy may be eligible if therapy was discontinued at least 28-days prior to screening.
* Treatment with systemic anti-infective therapy within 28-days prior to screening.
* Participation in other clinical studies with investigational agents within 8 weeks prior to screening.
* Treatment with NO and other NO donor agents, phosphodiesterase inhibitors and lung surfactant drugs, within 30 days prior to screening.
* Treatment with immunosuppressive medications within 2 weeks prior to screening, or systemic corticosteroids, or immunoglobulin therapy for more than 7 days within 2 weeks prior to screening.
* HIV positive AND CD4 \< 350 cells/mm3
* FEV1 \<55% predicted at the screening visit.
* Significant haemoptysis within 60 days of screening defined as an estimated volume of 50ml at any time.
* History of methaemoglobinaemia.
* Taking medications that may induce methaemoglobinaemia, or have received these within 30 days of screening.
* Baseline SpMet \>5%.
* Current smokers of tobacco products, marijuana, e-cigarettes/vaping: a current smoker is defined as having inhaled any of these within 3 months of screening.
* In the opinion of the investigator, patients with an acute exacerbation of NCFB.
* In the opinion of the investigator, any other clinically relevant active respiratory disease with the potential to compromise participant safety or confound interpretation of safety or efficacy outcomes. Patients who have experienced \>2 exacerbations of asthma or COPD requiring treatment with systemic corticosteroids within the past 12 months are not eligible.
* Asthma which requires treatment with GINA steps 4-5 suggested medications i.e., high dose ICS and LABA or leukotriene modifier/theophylline for the previous year, or systemic corticosteroids for ≥50% of the previous year to prevent it from becoming "uncontrolled", or which remains "uncontrolled" despite this therapy.
* Patients with a diagnosis of primary ciliary dyskinesia.
* Patients with a diagnosis of pulmonary hypertension.
* Patients with a current diagnosis of TB based on clinical testing or symptoms. Patients with a history of TB who have completed a course or eradication therapy at least 2 years prior to screening may be eligible if there is no clinical suspicion of recurrence. Patients with latent TB are eligible provided they have received adequate treatment per local country guidelines.
* Patients with a diagnosis, or suspected diagnosis, of NTM infection according to the ATS/IDSA statement on diagnosis, treatment, and prevention of non-tuberculous mycobacterial diseases. Patients with a previous positive culture that is suspected to be a contaminant are eligible.
* Symptomatic GERD causing NCFB disease.
* Conditions of increased risk for MetHb formation, significant anaemia or haemoglobinopathy.
* Known allergy to active substance or any excipients, or to auxiliary product.
* Known hypersensitivity to NO.
* History of anaphylaxis to any medication or hospitalisation due to an adverse drug reaction (ADR).
* Patients who are pregnant or breastfeeding.
* Patients planning to conceive a child within the anticipated period of study participation and for at least 90-days after the last dose of IMP in the study.
* Patients unable or unwilling to comply with the protocol or to cooperate fully with the investigator or site personnel.
* Alcohol or drug abuse, that in the opinion of the investigator, is sufficient to compromise the safety or cooperation of the participant.
* Patients with the following toxicities at screening as defined by the enhanced CTCAE toxicity table version 5.0, 27Nov2017.

  1. creatinine \>1.5 times upper limit of normal (ULN)
  2. haemoglobin ≤8.0 g/dL
  3. platelets \<50x10\^9 cells/L
  4. serum potassium \<3.5 mmol/L
  5. aspartate aminotransferase (AST) \>3 x ULN
  6. alanine aminotransferase (ALT) \>3 x ULN
  7. alkaline phosphatase (ALP) ≥ 2.5 x ULN
  8. total bilirubin \>1.5 x ULN
  9. total white cell count \<2 cells x 10\^9/L.
* QTcF \>450 milliseconds (males) or 470 milliseconds (females) or history of congenital long QT syndrome, Torsades de Pointes or other clinically significant abnormal ECG at screening or baseline.
* History of solid organ transplantation.
* History of malignancy or treatment for malignancy within the past year.

Where this trial is running

Kyiv

• ARENSIA Exploratory Medicine — Kyiv, Ukraine (Recruiting)

Study contacts

• Study coordinator: Katie Crevel

Conditions Non-Cystic Fibrosis Bronchiectasis; Nitric Oxide