National cohort for patients with antiphospholipid syndrome in China
Official title: Chinese AntiphosPholipid Syndrome cohorT cOllaborative NEtworks
Run by Peking Union Medical College Hospital · NCT05230017 · Data updated 2026-11-12
This study is trying to learn more about antiphospholipid syndrome by following 2,000 patients in China with positive antiphospholipid antibodies to see how it affects their health over time.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 2000 (estimated) |
| Sponsor | Peking Union Medical College Hospital Academic / other |
| Locations | 18 sites (Beijing, Beijing Municipality and 17 other locations) |
| Status | Recruiting |
| Started | October 1, 2022 |
| Main results expected | December 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | July 30, 2024 |
| Trial ID | NCT05230017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are individuals with one or more antiphospholipid antibodies present on two or more occasions at least 12 weeks apart.
✕Probably not a fit
Patients who refuse to participate or are unable to be followed will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This project aims to establish the first multicenter cohort of patients in China with persistently positive antiphospholipid antibodies (aPLs) to better understand antiphospholipid syndrome (APS). The study will enroll 2000 patients from six centers, led by Peking Union Medical College Hospital, and will focus on comprehensive clinical phenotyping, including thrombotic and pregnancy events. Patients will be followed every six months for up to three years to assess event risk and prognosis, as well as the clinical significance of extra-standard antibodies. The findings may help refine detection criteria for aPLs in the Chinese population.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnosis and management of antiphospholipid syndrome in patients with persistent aPLs.
How similar studies have gone: While there have been studies on antiphospholipid syndrome, this cohort approach in China is novel and aims to fill a significant gap in large-scale research.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The presence of one or more of the antiphospholipid antibodies (aPL) tested according to the 2006 Sapporo APS clasification criteria, on two or more occasions at least 12 weeks apart: Exclusion Criteria: * Patients refuse to participate; * Unable to be followed.
Where it's running
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, China Recruiting -
Beijing Shunyi Hospital
Beijing, Beijing Municipality, China Recruiting -
Fujian Medical University Union Hospital
Fuzhou, Fujian, China Recruiting -
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China Recruiting -
Shenzhen People's Hospital
Shenzhen, Guangdong, China Recruiting -
The Second People's Hospital of Shenzhen
Shenzhen, Guangdong, China Recruiting
Show 12 more locations
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The First Affiliated Hospital of Guangxi Medical University
Nanning, Guangxi, China Recruiting -
The Affilicated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China Recruiting -
Jiangsu Province Hospital
Nanjing, Jiangsu, China Recruiting -
The Second Affiliated Hospical of Nanchang University
Nanchang, Jiangxi, China Recruiting -
The Second Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China Recruiting -
The First Hospital of China Medical University
Shenyang, Liaoning, China Recruiting -
Qilu Hospital of Shandong University
Jinan, Shandong, China Recruiting -
Ruijin Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China Recruiting -
Tianjin Medical University Genral Hospital
Tianjin, Tianjin Municipality, China Recruiting -
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China Recruiting -
First People's Hospital of Yunnan Province
Kunming, Yunnan, China Recruiting -
The Second Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, Zhejiang, China Recruiting
Study contacts
- Principal investigator: Jiuliang Zhao, M.D. — Peking Union Medical College Hospital
- Study coordinator: Jiuliang Zhao, M.D.
- Email: Jiuliang.zhao@cstar.org.cn
- Phone: 0086-13810103105
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
AIHA in antiphospholipid syndrome: what it means for APS patients
This study tests how autoimmune hemolytic anemia affects people with antiphospholipid syndrome and what it means for their risk of clots and organ problems.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.