Naringenin supplementation for patients with bone fractures
Effect of Naringenin Supplementation on the Speed of Bone Fusion and the Concentration of Plasma Inflammatory Factors in Patients With Bone Fractures.
This study is testing if taking naringenin, a natural supplement from citrus fruits, can help patients with lower limb bone fractures heal faster and feel less inflammation after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 70 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Shahid Beheshti University of Medical Sciences Academic / other |
| Locations | 1 site (Tehran) |
| Trial ID | NCT06612762 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of naringenin, a natural flavonoid found in citrus fruits, on patients with lower limb bone fractures. It aims to determine whether naringenin can accelerate bone healing and reduce inflammation following orthopedic surgery. Eligible participants will be randomly assigned to receive either naringenin capsules or a placebo, with careful monitoring of their health and capsule consumption. The study is conducted at Ayatollah Taleghani University Hospital in Tehran, focusing on hospitalized patients who meet specific inclusion criteria.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 who are scheduled for orthopedic surgery due to lower limb fractures and meet specific health criteria.
Not a fit: Patients with chronic inflammatory diseases, advanced kidney failure, or those taking medications that affect bone metabolism may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could enhance recovery and reduce complications for patients with bone fractures.
How similar studies have performed: While the use of naringenin in this context is novel, previous studies have shown its potential benefits in other inflammatory and bone-related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Candidate for orthopedic surgery for bone fractures of the lower limbs, * Ambulatory without assistance for a minimum of two months prior to the fracture. * Not having undergone amputation of the lower limbs. * Not suffering from liver cirrhosis. * Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL). * Not having metastatic cancer, any chronic inflammatory diseases, nor taking any drugs that affect bone metabolism, including calcitonin, bisphosphonates, and corticosteroids. Exclusion Criteria: * Allergy or intolerant reaction to narangenin capsules * Any abnormal changes in their liver, kidneys tests, * Failure to consume more than 10% of their capsules
Where this trial is running
Tehran
- Ayatollah Taleghani Educational Hospital — Tehran, Iran (Recruiting)
Study contacts
- Study coordinator: Faeze Gohari, M.S.
- Email: gouhari71nutr@gmail.com
- Phone: 2122077424
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.