Naringenin supplementation for patients with bone fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of naringenin, a natural flavonoid found in citrus fruits, on patients with lower limb bone fractures. It aims to determine whether naringenin can accelerate bone healing and reduce inflammation following orthopedic surgery. Eligible participants will be randomly assigned to receive either naringenin capsules or a placebo, with careful monitoring of their health and capsule consumption. The study is conducted at Ayatollah Taleghani University Hospital in Tehran, focusing on hospitalized patients who meet specific inclusion criteria.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Candidate for orthopedic surgery for bone fractures of the lower limbs,
* Ambulatory without assistance for a minimum of two months prior to the fracture.
* Not having undergone amputation of the lower limbs.
* Not suffering from liver cirrhosis.
* Not suffering from advanced kidney failure (blood creatinine higher than 1.4 mg/dL).
* Not having metastatic cancer, any chronic inflammatory diseases, nor taking any drugs that affect bone metabolism, including calcitonin, bisphosphonates, and corticosteroids.

Exclusion Criteria:

* Allergy or intolerant reaction to narangenin capsules
* Any abnormal changes in their liver, kidneys tests,
* Failure to consume more than 10% of their capsules

Where it's running

• Ayatollah Taleghani Educational Hospital
  Tehran, Iran Recruiting

Study contacts

• Study coordinator: Faeze Gohari, M.S.
• Email: gouhari71nutr@gmail.com
• Phone: 2122077424

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.