Nano-Silver Fluoride versus Bioactive Glass Gel for Teeth in Children Undergoing Head and Neck Radiotherapy
Official title: Antimicrobial and Remineralization Efficacy of Nano-Silver Versus Bioactive Glass on Primary Teeth Exposed to Therapeutic Radiation
Run by Faculty of Dental Medicine for Girls · NCT07866482 · Data updated 2026-11-12
This study tests whether nano silver fluoride or bioactive glass gel can help prevent or reduce radiation-related tooth damage in kids aged 6-10 who are receiving head and neck radiotherapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 6 Years to 10 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Faculty of Dental Medicine for Girls Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Cairo, Cairo Governorate) |
| Status | Recruiting |
| Started | July 11, 2026 |
| Main results expected | December 31, 2026 |
| Study ends | February 15, 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT07866482 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children aged 6-10 years undergoing therapeutic head and neck radiotherapy with at least one sound primary tooth.
✕Probably not a fit
Participants with extensive caries or enamel defects, edentulous jaws, or conditions affecting salivary flow unrelated to radiotherapy may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial includes both lab (in vitro) and clinical (in vivo) components to compare two remineralization and antimicrobial approaches. In the lab portion, extracted sound primary molars will be exposed to radiation and then treated with either nano silver fluoride or bioactive glass, with assessments of surface morphology, mineral content, and microhardness. In the clinical portion, 30 pediatric patients will be randomized to receive a single application of nano silver fluoride or daily bioactive glass gel for seven days, with measurements of salivary pH and bacterial counts before and after treatment. The study aims to understand how these interventions affect enamel integrity and the oral environment in radiated teeth. Radiographic and microbiological analyses will be used to characterize changes over the study period.
Why it matters
Potential benefit: If successful, the interventions could reduce enamel weakening and bacterial burden in teeth exposed to radiotherapy, potentially lowering the risk of radiation caries.
How similar studies have gone: Prior work has explored remineralizing agents for radiotherapy-related dental changes, but this direct head-to-head comparison in this specific pediatric radiotherapy setting is novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pediatric patients undergoing therapeutic head and neck radiotherapy. * Age 6 to 10 years. * Presence of at least one sound primary tooth. * The oral cavity lies within the radiotherapy field during treatment. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Systemic diseases affecting tooth mineralization. * Use of medications known to influence salivary flow or enamel integrity, other than radiotherapy. * Edentulous upper and lower jaws. * Extensive dental caries or severe enamel defects. * Habitual mouth breathing. * Uncooperative patients or lack of parental consent.
Where it's running
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National Cancer Institute, Cairo University
Cairo, Cairo Governorate, Egypt Recruiting
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.