Nalbuphine versus fentanyl to reduce blood pressure and heart rate changes during laryngoscopy and intubation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for cardiac surgery will receive standard premedication and invasive monitoring including central venous and arterial lines, then be given either nalbuphine (0.2 mg/kg) or fentanyl (3 µg/kg) intravenously before induction with etomidate and muscle relaxation with atracurium. Endotracheal intubation will be performed under direct laryngoscopy and hemodynamic parameters (heart rate and arterial blood pressure) will be recorded continuously around the time of laryngoscopy and during the intraoperative period. Anesthesia will be maintained with sevoflurane and a continuous atracurium infusion while measurements are compared between the two opioid groups to determine which drug better blunts the laryngoscopic stress response. Standard exclusion criteria include asthma, significant renal or hepatic dysfunction, extreme obesity, pregnancy or lactation, and anticipated difficult or prolonged intubation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Weighing 40-70kg

  * ASA III of either sex
  * Undergoing cardiac surgery with CPB

Exclusion Criteria:

• History of Drug Allergy • Pre-existing Asthma • Renal or Hepatic dysfunction • Extreme obesity • Pregnant / lactating patients • Difficult intubation/prolonged intubation

Where it's running

• Deparment of Anesthesia, Rawalpindi Institute of Cardiology, Rawalpindi
  Rawalpindi, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Ayemon Principal Investigator, MBBS
• Email: ayemonfatima@gmail.com
• Phone: +923211579066

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.