N-acetylcysteine supplementation's effect on exercise performance
Assessment of the Impact of N-acetylcysteine Supplementation on Physical Performance Depending on the Polymorphism of Genes Related to Folate Metabolism
This study is testing if taking N-acetylcysteine can help people who do endurance sports perform better, while also looking at how this might differ based on their genes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Poznan University of Life Sciences Academic / other |
| Locations | 1 site (Poznań) |
| Trial ID | NCT05604586 on ClinicalTrials.gov |
What this trial studies
This study investigates whether N-acetylcysteine (NAC) supplementation can enhance exercise capacity in individuals engaged in endurance sports, and how this effect may vary based on specific gene polymorphisms related to folate and glutathione metabolism. It involves a double-blind, placebo-controlled design with 100 participants who will receive either NAC or a placebo for seven days. The study will assess exercise performance and biochemical parameters before and after the intervention, alongside blood sampling and body composition analysis.
Who should consider this trial
Good fit: Ideal candidates are healthy individuals aged 18 to 45 who train at least four times a week.
Not a fit: Patients with existing health conditions, such as blood disorders or respiratory diseases, or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved exercise performance and recovery strategies for athletes based on genetic profiles.
How similar studies have performed: While the specific combination of NAC supplementation and genetic polymorphism assessment is novel, previous studies have shown potential benefits of NAC in exercise performance.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Consent to participate in the study and acceptance of the established scheme for conducting the intervention * age range between 18 and 45 years old * regular training with a frequency of at least 4 times a week during the last year, Exclusion Criteria: * no consent to participate in the study and no acceptance of the established scheme of the conducted intervention * existing diseases of the blood system and neoplastic diseases * respiratory system diseases * obesity * any medical contraindications to exercise * Results obtained from exercise tests that do not meet the inclusion criteria * use of NAC during the last month * allergy to NAC * smoking * pregnancy and lactation
Where this trial is running
Poznań
- Poznan University of Life Science — Poznań, Poland (Recruiting)
Study contacts
- Principal investigator: Marcin Sadowski, MSc — Poznań University of Life Science
- Study coordinator: Agata Chmurzyńska, Professor
- Email: agata.chmurzynska@up.poznan.pl
- Phone: 61 8466181
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.