Multispectral optoacoustic tomography for imaging muscles in centronuclear myopathy
Official title: Multispectral Optoacoustic Tomography for Advanced Imaging of Centronuclear Myopathy
Run by University of Erlangen-Nürnberg Medical School · NCT07021820 · Data updated 2026-11-12
This uses a painless MSOT scanning method to try to image muscles in people with centronuclear myopathy and in matched healthy volunteers for comparison.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 2 Years and up |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Erlangen-Nürnberg Medical School Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Erlangen, Bavaria) |
| Status | Recruiting |
| Started | May 29, 2025 |
| Main results expected | October 31, 2025 |
| Study ends | December 31, 2026 |
| Registry record updated | June 15, 2025 |
| Trial ID | NCT07021820 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
People aged 2 years and older with a confirmed diagnosis of centronuclear myopathy who can attend the Erlangen site and meet the scan safety criteria are ideal candidates.
✕Probably not a fit
Those who are pregnant or nursing, have tattoos over the examination area, have more than 3 cm of subcutaneous fat at the scan site, or healthy volunteers should not expect direct clinical benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational project will enroll 20 patients with centronuclear myopathy and 20 age- and sex-matched healthy controls. Participants undergo a physical exam, clinical and functional testing, and multispectral optoacoustic tomography (MSOT) scans at predefined muscle sites (paraspinal, trapezius, deltoid, forearm flexors, quadriceps, adductors, ischiocrural muscles, triceps surae, and tibialis anterior). The protocol is noninvasive and excludes children under 2 years, pregnant or nursing women, people with tattoos in the scan area, or those with more than 3 cm of subcutaneous fat at the scan site. Imaging and clinical data will be compared between groups to identify MSOT features associated with centronuclear myopathy.
Why it matters
Potential benefit: If successful, this could provide a noninvasive imaging method to better visualize muscle changes and help monitor disease progression or response to future treatments.
How similar studies have gone: MSOT has shown promise in other muscle and vascular imaging research, but its specific application to centronuclear myopathy is novel and limited in published data.
Who can join: the full rules
Show full inclusion / exclusion criteria
CNM arm: Inclusion Criteria: diagnosed CNM; minimum of 2 years of age Exclusion Criteria: * Pregnancy * Nursing mothers * Tattoo in the area of the examination field * Subcutaneous fatty tissue \> 3 cm HV: Inclusion criteria: minimum of 2 years of age Exclusion criteria: * any signs/history of muscle diseases * Pregnancy * Nursing mothers * Tattoo in the area of the examination field * Subcutaneous fatty tissue \> 3 cm
Where it's running
-
Uniklinikum Erlangen
Erlangen, Bavaria, Germany Recruiting
Study contacts
- Study coordinator: Lina Tan
- Email: Lina.Tan@uk-erlangen.de
- Phone: +49 9131 85-41277
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Understanding muscle fatigability in congenital myopathies
This study is trying to understand how muscle fatigue affects people with congenital myopathies like Central Core Disease and Nemaline Myopathy over two years.
-
Collecting data on muscle disorders using wearable devices
This study is testing a wearable device to track movement in people with muscle disorders like Duchenne Muscular Dystrophy and Myotonic Dystrophy to see how it can help improve their care.
-
Registry for patients with myotubular and centronuclear myopathy
This study is creating a registry to gather information from people with myotubular and centronuclear myopathy to help find participants for clinical trials and improve care for these conditions.
-
Research on genetic causes of congenital myopathies
This study is trying to find out more about the genetic causes of congenital myopathies to help improve diagnosis and treatment for people born with these muscle diseases.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.