Multimodal lifestyle program to lower dementia risk and shift attitudes about dementia risk
Impact of a Multimodal Lifestyle Intervention on Dementia Risk Factors and Attitude Related to Dementia Risk: A Logistical Pilot Study
This pilot tests whether a multimodal lifestyle program can reduce dementia risk factors and change attitudes among cognitively normal 65–75-year-olds who have a family history of dementia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 65 Years to 75 Years |
| Sex | All |
| Sponsor | HudsonAlpha Institute for Biotechnology Academic / other |
| Locations | 1 site (Huntsville, Alabama) |
| Trial ID | NCT07146412 on ClinicalTrials.gov |
What this trial studies
This logistical pilot offers a personalized multimodal lifestyle intervention—including exercise, diet, cognitive activities, and other risk-factor modifications—to cognitively normal older adults aged 65–75 with a first-degree relative with dementia. Participants will complete baseline cognitive testing (MoCA >24 required), surveys about dementia risk attitudes, and provide biosamples for blood-based Alzheimer biomarkers; they will then receive the intervention with ongoing data collection. The study will monitor changes in modifiable risk factors and in participants' attitudes after they learn personalized risk information. The project is being run at a single center to test data collection, processing, and delivery workflows for a larger future trial.
Who should consider this trial
Good fit: Ideal candidates are English-speaking adults age 65–75 with at least one first-degree relative with dementia, normal cognition (MoCA >24), and regular access to a smartphone, tablet, or PC with internet.
Not a fit: People who already have diagnosed cognitive impairment, mild cognitive impairment, or dementia (or a MoCA score <25), non-English speakers, or those without internet access will not qualify and are unlikely to benefit from this pilot.
Why it matters
Potential benefit: If successful, the program could help at-risk older adults reduce modifiable risk factors and adopt behaviors that delay or lower their chance of developing Alzheimer's disease.
How similar studies have performed: Previous multimodal lifestyle trials such as the FINGER trial have shown that combined diet, exercise, and cognitive interventions can slow cognitive decline in at-risk older adults, so this pilot builds on promising, established approaches.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 65-75 years of age at enrollment with at least one self-reported 1st-degree relative who had or has any kind of dementia * Montreal Cognitive Assessment (MoCA) score \> 24 at initial enrollment * Able and willing to comprehend and sign the informed consent document * Able and willing to perform required physical performance tests * Able and willing to provide the study's minimum samples * Able and willing to conduct the study's minimum procedures * Able and willing to complete surveys, cognitive assessments, and questionnaires in English only * Has or has ready access to a PC, tablet, or smartphone with an internet connection required for procedures that they consent to Exclusion Criteria: * A diagnosis of cognitive impairment of any kind, including Alzheimer's disease, mild cognitive impairment, or any other diagnosis of dementia * If a subject is found to have cognitive impairment at initial enrollment (Montreal Cognitive Assessment (MoCA) score\<25), they will be excluded from the study * Self-reported pregnancy * Children under 19 years of age * Individuals not fluent in written and spoken English * Self-reported chronic or end-stage disease that would interfere with their participation in the study * Hospitalization for any reason in the past 3 months * Severe hearing and visual impairment that would interfere with the ability to complete study measures * Any other vulnerable subject at the time of enrollment as specified above
Where this trial is running
Huntsville, Alabama
- Smith Family Clinic for Genomic Medicine — Huntsville, Alabama, United States (Recruiting)
Study contacts
- Study coordinator: Jesse N Cochran, PhD
- Email: ncochran@hudsonalpha.org
- Phone: 256-327-5262
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.