Multimodal heart and liver imaging in adults from the Constances cohort
Multimodal Cardiovascular and Hepatic Population Imaging
Institut National de la Santé Et de la Recherche Médicale, France · NCT06906042
This project uses advanced heart and liver imaging to see if scans can reveal early signs of disease in adults from the Constances population cohort.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 2400 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Institut National de la Santé Et de la Recherche Médicale, France (other gov) |
| Locations | 1 site (Paris) |
| Trial ID | NCT06906042 on ClinicalTrials.gov |
What this trial studies
The project will create a large linked collection of cardiac and hepatic images and associated health data from Constances cohort participants using MRI, echocardiography and standardized paramedical and medical examinations. Participants are adults without known cardiovascular or liver disease who undergo noninvasive imaging and clinical data collection. The resulting multimodal dataset will be analyzed to distinguish normal aging from early disease and to explore how age, sex, genetics and environment relate to residual individual risk. The effort is observational and centralized at Hôpital Pitié‑Salpêtrière with images linked to existing cohort data for long‑term research.
Who should consider this trial
Good fit: Ideal candidates are adults (age ≥ 20) who are enrolled in the Constances cohort, have no known cardiovascular or hepatic disease, and can safely undergo MRI.
Not a fit: People with symptomatic heart or liver disease, significant renal impairment (GFR < 60 mL/min/1.73m2), pregnancy, or MRI contraindications are unlikely to gain benefit from this imaging-focused project.
Why it matters
Potential benefit: If successful, the imaging collection could help clinicians spot early heart and liver changes and improve personalized risk predictions.
How similar studies have performed: Large population imaging initiatives (for example cardiac MRI work in population biobanks) have successfully identified subclinical markers, supporting the value of a multimodal imaging approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participation to the Constances cohort * Age ≥ 20 years * No overt cardiovascular or hepatic disease or related symptoms * No known family or personal genetic disease * Affiliation with a social security scheme or beneficiary of such a scheme. * Agreement to sign the consent Exclusion Criteria: * Renal function impairment with GFR \< 60 mL/min/1.73m2 * Deprived of liberty or persons subject to a legal protection measure (under guardianship or trusteeship) * People with contraindications to MRI (claustrophobia, presence of metallic elements…) * Pregnant or breastfeeding woman (pregnancy urinary test before inclusion for women of childbearing age).
Where this trial is running
Paris
- Hôpital Pitié-Salpêtrière — Paris, France (RECRUITING)
Study contacts
- Study coordinator: Alban M Redheuil, PU-PH
- Email: alban.redheuil@aphp.fr
- Phone: +33142165545
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy Volunteers, Imaging Evaluation, multimodal imaging, heart, liver, Constances cohort, population, Cardiac imaging