Multi-sensor mapping of heart mechanics and rhythm during exercise in healthy adults
Study on the 'Seismocardiography-Electrocardiography' Coupling Dynamics and Its Exercise-load Reactivity Model in Healthy Individuals
This trial will test whether chest-worn sensors that record seismocardiography and a single-lead ECG can show how heart mechanics and heart rate change together as healthy adults walk at increasing treadmill speeds.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 270 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Shanghai Ruiwei Digital Technology Co. Ltd. Industry-sponsored |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Trial ID | NCT06952673 on ClinicalTrials.gov |
What this trial studies
Participants wear a precordial inertial sensor (IMU) for seismocardiography (SCG) and a single‑lead precordial ECG while performing graded-speed treadmill sessions between 3 and 8 km/h. Oxygen uptake (VO₂) from CPET is used to index exercise intensity while SCG and ECG are recorded simultaneously to characterize mechanical and electrical cardiac responses. The protocol examines how SCG-ECG dynamic coupling varies across incremental exercise loads and aims to quantify relationships among exercise load, heart rate, and contractility. Data will be analyzed to identify reproducible responsivity patterns and potential intrinsic rules linking the three domains.
Who should consider this trial
Good fit: Healthy adults aged 18–60 years who have no significant medical history, can safely walk on a treadmill, and can provide informed consent are ideal candidates.
Not a fit: People with known cardiovascular, pulmonary, severe systemic illnesses, mobility-limiting musculoskeletal conditions, pregnancy, or uncontrolled hypertension are unlikely to benefit or be eligible.
Why it matters
Potential benefit: If successful, this work could enable wearable-based, noninvasive tracking of how heart contractility and rate adapt to exercise, improving remote physiological monitoring.
How similar studies have performed: Previous small studies have shown that SCG and ECG can be recorded during exercise and yield useful signals, but comprehensive analysis of triadic coupling under graded treadmill conditions is largely novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-60 years * Healthy individuals with no significant medical history * Signed informed consent as an acceptance to participate to the trial Exclusion Criteria: * History of severe cardiovascular, cerebrovascular, pulmonary, hepatic, renal, psychiatric, or other critical systemic disorders * Peripheral vascular diseases, musculoskeletal disorders, or other conditions limiting physical mobility * Uncontrolled hypertension (systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg) * History of anemia * Moderate to severe obesity (BMI ≥32.5 kg/m²) * Pregnant or lactating women * Any other conditions deemed ineligible for participation per investigator's discretion
Where this trial is running
Shanghai, Shanghai Municipality
- Building 16, Lane 775, Hangdong Road, Shanghai — Shanghai, Shanghai Municipality, China (Recruiting)
Study contacts
- Study coordinator: SEN WANG, M.D., Ph. D.,
- Email: 13916165236@163.com
- Phone: +86 13916165236
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.