Multi-omics analysis of iNPH and ventriculoperitoneal shunt outcomes

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants undergo preoperative T1-weighted, functional, and diffusion MRI and clinical assessments including MMSE, gait scores, Kiefer score, and modified Rankin Scale before and after a lumbar tap test and again six months after VP shunt surgery. Cerebrospinal fluid is collected at the tap test and from the VP device pump six months post‑surgery for proteomic analysis. The study combines CSF proteomics with structural and functional MRI analyses to identify biological and imaging prognostic factors linked to shunt response. Data are collected at The Second Affiliated Hospital, School of Medicine, Zhejiang University with Westlake University collaboration.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 60 years;
* Diagnosis of iNPH based on clinical assessment
* Participant is able to give written informed consent

Exclusion Criteria:

* Combining AD and Parkinson's disease and other nervous system diseases
* Participant is not medically available for shunt surgery
* Secondary NPH

Where it's running

• The second affliated hospital of zhejiang university
  Hangzhou, Zhejiang, China Recruiting

Study contacts

• Principal investigator: Zhoule Zhu — Second Affiliated Hospital, Zhejiang University, School of Medicine
• Study coordinator: Junming Zhu, M.D.
• Email: dr.zhujunming@zju.edu.cn
• Phone: 86-13968055768

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.