Multi-modal virtual reminiscence therapy with an AI avatar for older adults with Alzheimer's and related dementias

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patient–caregiver dyads are randomized to receive Smart Virtual Reminiscence (SVR) therapy delivered by a multi-modal avatar or an attention control of listening to music. SVR is a computer-accessible program that uses large language model–driven speech understanding, avatar nonverbal cues, and automatically assembled personal reminiscence materials (photos, music, videos) so a human facilitator is not required. Sessions can be completed at the study site or at home via a reliable internet connection with caregiver support as needed. The study measures changes in behavioral and psychological symptoms of dementia using caregiver- and self-report instruments.

Why it matters

Who can join: the full rules

For the patient:

Inclusion criteria:

* age ≥ 65 years
* diagnosis of MCI (mild cognitive impairment) or mild ADRD
* access to a reliable internet connection
* community-dwelling
* elevated behavioral and psychological symptoms of dementia (BPSD), indicated by a HABC (Healthy Aging Brain Care) monitor score above 14 on caregiver report or self report (indicating elevated levels of BPSD)
* presence of one or more specific BPSD behaviors (e.g., agitation, anxiety, depression, apathy, or sleep disturbances)
* ability to consent for themselves.

Exclusion criteria:

* lives in an assisted living facility or nursing home
* has moderate to severe ADRD as measured by the Quick Dementia Rating System
* has a life expectancy of less than 6 months.

For the care partner:

Inclusion criteria:

* ≥ 21 years old
* self-identified care partner (e.g., is knowledgeable about the patient's daytime and nighttime behaviors) of a community-dwelling patient diagnosed with MCI or mild ADRD who will also participate in the study

Exclusion criteria:

* has MCI or dementia
* has a severe mental illness or substance abuse
* has a life expectancy of less than 6 months.

Where it's running

• Sidney & Lois Eskenazi Hospital
  Indianapolis, Indiana, United States Recruiting

Study contacts

• Principal investigator: Malaz Boustani, MD, MPH — Indiana University
• Study coordinator: Katrina Coppedge, BA
• Email: kcoppedg@iu.edu
• Phone: 317-278-1602

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.