Mulberry leaf extract capsule for blood sugar in healthy adults
Official title: Safety of Mulberry Leaf Extract Capsule on Blood Glucose Control in Healthy Volunteer
Run by Chulalongkorn University · NCT07532135 · Data updated 2026-11-12
This trial tests whether taking a mulberry leaf extract capsule three times a day for eight weeks is safe and affects blood sugar in adults without diabetes.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 48 (estimated) |
| Sponsor | Chulalongkorn University Academic / other |
| Locations | 1 site (Bangkok) |
| Status | Recruiting |
| Started | October 1, 2025 |
| Main results expected | September 1, 2026 |
| Study ends | September 24, 2026 |
| Registry record updated | April 23, 2026 |
| Trial ID | NCT07532135 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older without diagnosed diabetes (fasting glucose <126 mg/dL and HbA1c <6.5), able to use Thai and willing to attend visits at the Bangkok site are appropriate candidates.
✕Probably not a fit
People with diagnosed diabetes, on glucose-altering medications, with significant liver or kidney impairment, or who are pregnant or breastfeeding are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Healthy adults without diabetes or with non-diabetic hyperglycemia were assigned to receive either mulberry leaf extract capsules (DNJ 12 mg) or placebo three times daily for eight weeks. Safety labs (CBC, BUN, creatinine, AST, ALT, ALP), fasting plasma glucose, HbA1c, and adverse events were measured at baseline and after 4 and 8 weeks, and participant satisfaction was recorded at 8 weeks. The primary focus is on tolerability and laboratory safety signals rather than therapeutic efficacy. Findings will inform whether further clinical testing is warranted in people with elevated blood sugar.
Why it matters
Potential benefit: If safe and well tolerated, the extract could become an accessible supplement option to help manage blood sugar in people without diabetes.
How similar studies have gone: Prior small trials of mulberry leaf (DNJ) have reported modest reductions in postprandial glucose, but larger, definitive clinical data remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male or female age more than 18 years * No Diabetis mellitus disease and no taking diabetes medication * Blood sugar level less than 126 mg/dl and HbA1C less than 6.5 * Can using Thai language * Willing to participate in the study Exclusion Criteria: * Allergic to mulberry extract * Take mulberry extract in 2 weeks before participate in this study * Take medications that have effect on blood sugar level such as steroid in 2 weeks before participate in this study * Have uncontrolled disease * Have AST, ALT, ALP more than 3 times of normal value, or estimated Glomerular Filtration Rate less than 30 ml/min/1.73 m2) * Pregnancy or lactation
Where it's running
-
Chulalongkorn
Bangkok, Thailand Recruiting
Study contacts
- Study coordinator: Pornanong Aramwit, Ph.D
- Email: aramwit@gmail.com
- Phone: +66899217255
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.