MRI to predict who will respond to dienogest for endometriosis
Predicting the Efficacy of Dienogest in Patients With Endometriosis Using MRI
We will test whether MRI scans can predict which women with endometriosis will get pelvic pain relief from dienogest.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 48 (estimated) |
| Ages | 19 Years to 45 Years |
| Sex | Female |
| Sponsor | Chungnam National University Sejong Hospital Academic / other |
| Locations | 1 site (Sejong, Sejong Special Self-Governing City) |
| Trial ID | NCT07446608 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study enrolling women aged 19–45 with clinician-diagnosed endometriosis who are starting dienogest as part of routine care. Participants will have baseline MRI imaging of endometriotic lesions and standard clinical follow-up including pelvic pain assessments. The study does not change treatment; it tracks outcomes to see if MRI features at baseline link with later pain improvement. Key exclusions include prior dienogest use, recent hormonal therapy, pregnancy or MRI contraindications, and enrollment is at Sejong Chungnam National University Hospital.
Who should consider this trial
Good fit: Women aged 19–45 with a diagnosis of endometriosis who have not used dienogest before, have had no hormonal treatment in the prior 3 months, and are about to start dienogest are ideal candidates.
Not a fit: Patients who have previously used dienogest, cannot undergo MRI, are pregnant or planning pregnancy within six months, or have contraindications to dienogest are unlikely to benefit from this prediction approach.
Why it matters
Potential benefit: If successful, MRI-based markers could help doctors choose dienogest for patients most likely to benefit, avoiding ineffective treatment and shortening time to relief.
How similar studies have performed: Imaging has been used to describe endometriosis lesions, but using MRI specifically to predict response to dienogest is relatively novel with limited prior evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female participants who have received a full explanation of the study and have provided written informed consent * Women aged 19 to 45 years who have been diagnosed with endometriosis by a board-certified obstetrician-gynecologist * Patients who have not received any hormonal treatment within the previous 3 months * Patients who have never been treated with dienogest Exclusion Criteria: * Patients with a history of treatment with dienogest * Patients with contraindications to dienogest * Patients who are unable to undergo magnetic resonance imaging (MRI) (e.g., presence of metallic implants) * Patients who are currently pregnant or planning pregnancy within the next 6 months * Patients with poor general medical condition, as judged by the investigator
Where this trial is running
Sejong, Sejong Special Self-Governing City
- Sejong Chungnam National University Hospital — Sejong, Sejong Special Self-Governing City, South Korea (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.