MRI screening for men at high risk of prostate cancer
MRI Screening in Men at High Risk of Developing Prostate Cancer
This study tests if MRI scans can help find serious prostate cancers earlier in men who are at high risk for the disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | Male |
| Sponsor | University of Chicago Academic / other |
| Locations | 2 sites (Chicago, Illinois and 1 other locations) |
| Trial ID | NCT05608694 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of Magnetic Resonance Imaging (MRI) in identifying high-grade prostate cancers earlier in men who are at high risk of developing the disease. Participants will undergo MRI scans with gadolinium contrast to enhance imaging quality. The study will compare the MRI results of high-risk men to those without a predisposition to prostate cancer, assessing the role of genetic risk scores in screening. The goal is to improve early detection and treatment outcomes for prostate cancer.
Who should consider this trial
Good fit: Ideal candidates for this study are men aged 18 and older who are at high risk of developing prostate cancer and have no prior history of the disease.
Not a fit: Patients with a known history of prostate cancer or those who have undergone prostate resection or ablation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of high-grade prostate cancers, improving treatment options and outcomes for patients.
How similar studies have performed: Other studies have shown promise in using MRI for prostate cancer screening, indicating that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male age 18 and older * No known history of prostate cancer * No previous prostate resection or ablation (e.g. TURP, photovaporization) Exclusion Criteria: * Unable to tolerate MRI due to metal fragments or claustrophobia * Lack of a rectum * Hip arthroplasty
Where this trial is running
Chicago, Illinois and 1 other locations
- University of Chicago — Chicago, Illinois, United States (Recruiting)
- NorthShore University Health System - Glenbrook Hospital — Glenview, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Scott Eggener, MD — University of Chicago
- Study coordinator: Scott Eggener, MD
- Email: seggener@surgery.bsd.uchicago.edu
- Phone: 7737021001
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.