MRI imaging to understand asthma lung structure and function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This exploratory study involves 200 asthma patients who will undergo hyperpolarized noble gas MRI and various pulmonary function tests to investigate the relationship between lung structure and function. Participants will visit the Clinical Imaging Research Laboratories at Robarts Research Institute twice over three years, with additional visits for the first 60 subjects to enhance data reproducibility. The study includes comprehensive assessments such as sputum induction and dyspnea questionnaires, and patients will track their asthma control through self-assessments uploaded to a secure website.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects male and female aged 18-60 with a clinical diagnosis of asthma
* Smoking history ≤ 1 pack/year
* Subject understands the study procedures and is willing to participate in the study as indicated by signature on the informed consent
* Subject is judged to be in otherwise stable health on the basis of medical history
* Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)
* FEV1 \>60% predicted

Exclusion Criteria:

* Patient is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material
* Patient is unable to perform spirometry or plethysmography maneuvers
* Subject has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants.) (At the discretion of the MRI Technologist/3T Manager)
* In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia.
* Patient is pregnant

Where it's running

• Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre
  London, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Grace E Parraga, PhD — Robarts Research Institute, The University of Western Ontario
• Study coordinator: Grace E Parraga, PhD
• Email: gparraga@robarts.ca
• Phone: 519-931-5265

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.