MRI imaging of how muscles and joints function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study utilizes MRI and ultrasound imaging to investigate the interactions between muscles, tendons, and bones during motion. It aims to develop advanced tools for accurately measuring and visualizing musculoskeletal anatomy and function, particularly focusing on joint dynamics and impairments. By creating detailed 3D images of joint tissues under load, the study seeks to enhance the understanding of normal and impaired joint function, ultimately improving diagnosis and treatment methods for movement disorders.

Why it matters

Who can join: the full rules

* INCLUSION CRITERIA:

Affected Participants:

* Must be between the ages of 5-95 years.
* Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
* Adults 18 \>= years of age, they must be able to provide informed consent.
* Have the presence of a bone, muscle, soft tissue, connective tissue injury, impairment or related muscular skeletal system pathology.
* Ability to have an MRI Scan.

Healthy Volunteer Participants

* Must be between the ages of 5-95 years.
* Minors \< 18 years of age, they must be capable of providing assent (verbal or written) with parental or legal guardian permissions obtained.
* Adults 18 \>= years of age, they must be able to provide informed consent.
* Ability to have an MRI Scan.

EXCLUSION CRITERIA:

Affected Participants:

-For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.

Healthy Volunteer Participants

* Any relevant medical problems
* Clinical signs of an impairment in the joint/limb being studied.
* Any serious injury to the joint/limb being studied, previous surgery on the joint/limb being studied or extreme pain at the joint/limb being studied.
* Neurologic Pathology affecting the muscular skeletal system
* For the MR imaging portion of this study, all participants must complete the NIH Diagnostic Radiology screening questionnaire. If any potential contraindication is found, either the volunteer s doctor (with knowledge of the potential contraindication) or the radiology department at the NIH will be contacted to determine if the potential contraindication would exclude them from the specific MR scans being proposed.

Where it's running

• National Institutes of Health Clinical Center
  Bethesda, Maryland, United States Recruiting

Study contacts

• Principal investigator: Frances T Gavelli, Ph.D. — National Institutes of Health Clinical Center (CC)
• Study coordinator: Frances T Gavelli, Ph.D.
• Email: gavellif@cc.nih.gov
• Phone: (301) 451-7585

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.