MRI-guided focused radiotherapy for abdominal and lung tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational feasibility study uses a high-field MR-Linac to deliver stereotactic ablative radiotherapy (SABR) to tumors in the abdomen or central chest while actively imaging the target during treatment. The approach includes real-time gating, on-table adaptation, and acquisition of functional MR images without extra radiation to assess motion, deformation, and tumour biology. Investigators will record patient experience and tolerability, and compare clinical outcomes to patients treated on standard x-ray–guided machines using the UKCAT database. Optional research imaging will be collected from consenting participants to explore whether MRI-derived biological information could guide adaptive treatment in future trials.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Have no MRI contra-indications.
2. Eligible for abdominal SABR in accordance with the NHSE SABR Consortium Guidelines or eligible for central lung SABR in accordance with RTOG Guidelines.
3. Be able to give informed consent.
4. Anticipated life-expectancy \> 6 months.
5. Not more than 3 oligmetastatic sites treated in total per patients.
6. Performance status ≤ 2.
7. Willing to attend follow-up and have details collected on prospective basis for a minimum of 1 year.

Exclusion criteria:

1. Any contraindications to MRI identified after MRI safety screening including completion of an MRI Safety Screening Form.
2. Unable to tolerate MRI scans.
3. Any evidence of severe or uncontrolled systemic diseases which, in the view of the investigator make it undesirable for the patient to participate in the study.
4. Any evidence of significant clinical disorder or laboratory finding which, in the opinion of the investigator, make it undesirable for the patient to participate in the study.
5. Any patient known to have active hepatitis B, hepatitis C or human immunodeficiency virus (HIV).

Where it's running

• The Christie NHS Foundation Trust
  Manchester, United Kingdom, United Kingdom Recruiting

Study contacts

• Study coordinator: Clare Griffin
• Email: clare.griffin1@nhs.net
• Phone: 01614463000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.