MRI-based AI to classify and grade renal tumors
Official title: An MRI-Based Study of Intelligent Pathological Subtyping and Grading of Renal Tumors
Run by Cancer Institute and Hospital, Chinese Academy of Medical Sciences · NCT07743749 · Data updated 2026-11-12
This study tests AI methods on MRI data from adults with kidney tumors to see if they can identify tumor type and grade before surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 900 (estimated) |
| Sponsor | Cancer Institute and Hospital, Chinese Academy of Medical Sciences Academic / other |
| Locations | 1 site (Beijing) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | August 4, 2026 |
| Trial ID | NCT07743749 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with a diagnosed renal tumor who have available preoperative renal MRI and a corresponding pathological diagnosis (subtype and grade if applicable).
✕Probably not a fit
Patients without reliable MRI data or without a complete pathology record may not benefit from the study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational, non-interventional study that uses existing and new MRI data to train and evaluate artificial intelligence models for detecting renal tumors, determining their pathological subtype, and grading them histologically. The research combines retrospective and prospective data, with pathological results serving as the reference standard. No changes to diagnosis or treatment occur, and no extra procedures are required beyond standard care. Data will be de-identified prior to analysis, and multiple MRI sequences may be used to improve model performance. The aim is to support preoperative assessment and personalized management of renal tumors.
Why it matters
Potential benefit: If successful, the approach could assist clinicians in preoperative planning and treatment decisions by providing noninvasive tumor subtype and grade information.
How similar studies have gone: Prior studies in imaging plus AI for renal tumors have shown promise but similar comprehensive MRI-based subtyping and grading is still an evolving area.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 years or older. * Patients diagnosed with a renal tumor. * Availability of preoperative renal magnetic resonance imaging examinations. * Availability of a corresponding pathological diagnosis, including pathological subtype and, where applicable, histological grade. * Magnetic resonance images that can be successfully retrieved and are of - - sufficient quality for image analysis. Exclusion Criteria: * Absence of renal magnetic resonance imaging data. * Absence of a corresponding pathological diagnosis or insufficient pathological subtype or grading information. * Magnetic resonance images that cannot be retrieved, opened, or read. * Poor image quality that precludes reliable image annotation or artificial intelligence analysis.
Where it's running
-
Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College
Beijing, China Recruiting
Study contacts
- Study coordinator: Xiongjun Ye
- Email: yexiongjun@cicams.ac.cn
- Phone: 010-87787170
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Hyperspectral imaging to guide robot-assisted kidney tumor removal
Doctors are testing a new imaging method during robotic kidney surgery to see if it helps identify tumor tissue and blood flow in adults with kidney tumors up to 7 cm.
-
Neoadjuvant HIF-2α inhibitor with or without PD-1 antibody for resectable clear cell kidney cancer
This trial tests whether casdatifan alone or combined with zimberelimab can shrink tumors in people with resectable clear cell kidney cancer before surgery.
-
Comparing back (SARA) versus side (flank) positions for single-port robotic partial kidney tumor removal.
This will see if placing adults on their back using the SARA technique or on their side leads to fewer complications and faster recovery for people having single-port robotic partial nephrectomy for small kidney tumors.
-
Treating the main kidney tumor in metastatic kidney cancer during immunotherapy
This trial will see if adding surgery or radiotherapy to the main kidney tumor helps people with metastatic clear‑cell kidney cancer who are already benefiting from anti‑PD1–based therapy live longer.
-
Comparing robot-assisted kidney surgery in different positions
This study is testing if having kidney surgery with a robot while lying face down is better for recovery and results compared to the usual side position for patients with kidney tumors.
-
Comparing systemic treatment alone to systemic treatment with added radiotherapy for kidney cancer with few metastases
This study is testing if adding targeted radiation therapy to regular treatment can help people with kidney cancer that has spread a little to live longer without their cancer getting worse.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.