MRI and CT-guided radiation therapy for abdominopelvic sarcomas
Official title: Phase II Study of Magnetic Resonance Image and Computed Tomography-Guided Stereotactic Body Radiation Therapy for Abdominopelvic Sarcomas (MARS Trial)
Run by Jonsson Comprehensive Cancer Center · NCT06436612 · Data updated 2026-11-12
This study tests if using MRI and CT scans to guide radiation therapy can help people with abdominopelvic sarcomas by targeting tumors more accurately while protecting healthy tissue.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 12 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | Jonsson Comprehensive Cancer Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | May 30, 2024 |
| Main results expected | May 30, 2027 |
| Study ends | May 26, 2028 |
| Registry record updated | June 5, 2026 |
| Trial ID | NCT06436612 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 12 and older with histologically confirmed sarcoma that is either primary or recurrent and resectable.
✕Probably not a fit
Patients with active treatment for another malignancy or a history of prior irradiation to the treatment area may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effectiveness of MRI and CT-guided stereotactic body radiation therapy (SBRT) for patients with abdominopelvic sarcomas. Participants will receive radiation treatment daily for five consecutive days, followed by surgical removal of the primary tumor within 12 weeks. The approach aims to deliver precise radiation doses to tumors while minimizing exposure to surrounding healthy organs. The study will also involve careful planning and simulation to ensure optimal treatment delivery.
Why it matters
Potential benefit: If successful, this treatment could improve tumor control and reduce side effects for patients with abdominopelvic sarcomas.
How similar studies have gone: Other studies have shown promising results with similar radiation therapy techniques, indicating potential for success in this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Histologically confirmed sarcoma * Primary or recurrent disease involving the abdomen or pelvis * Resectable primary lesion * Age ≥ 12 years old * Karnofsky performance status (KPS) ≥ 70 or Eastern Cooperative Oncology Group (ECOG) 0-2 * If a woman is of childbearing potential, a negative serum or urine pregnancy test must be documented Exclusion Criteria: * Active treatment of a separate malignancy * History of prior irradiation to the area targeted for treatment
Where it's running
-
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, United States Recruiting
Study contacts
- Study coordinator: Christy Palodichuk
- Email: cpalodichuk@mednet.ucla.edu
- Phone: 3107942971
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.