MRI analysis of individuals with autism and their families

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project focuses on understanding the genetic and clinical aspects of Autism Spectrum Disorder (ASD) through neuroimaging techniques. It involves acquiring anatomical, diffusion, and functional MRI data from individuals diagnosed with ASD, their relatives, and control subjects. The study is part of a larger initiative examining genetic factors associated with ASD, leveraging data from over 600 previously recruited participants. The research aims to identify brain abnormalities linked to ASD and their heritability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* for patients:

  * being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
  * having an ASD fulfilling DSM-5 diagnostic criteria (APA, 2012). Diagnosis will be done by a clinical expert, with the support of structured instruments (ADI-R, ADOS-2)
  * having at least 24 Months
  * being affiliated with the French health insurance
  * having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)
* for relatives

  * being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
  * having at least 24 Months
  * being affiliated with the French health insurance
  * having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)
* for controls

  * being included in the main study "C16-89 - Study of genetic factors involved in ASD and related disorders"
  * having at least 24 Months
  * being affiliated with the French health insurance
  * having signed the informed consent (by proposant or by legal tutors if the subject is \<18 or under legal custody)

Non-inclusion criteria:

* for all subjects

  * severe mental retardation (IQ\<35 or developmental age\<18 months)
  * medical condition (either psychiatric or physical) not compatible with an inclusion
  * MRI counter indication
  * Current pregnancy or breastfeeding, assessed by questionnaire
  * Not willing to be informed of a brain abnormality diagnosed with MRI
* for the relatives

  \*discovery of non filiation during the genetic analyses
* for controls

  * Neurological history (except mental retardation)
  * Personal history of (checked with DIGS for Adults, Diagnostic Interview for Genetic Studies, Numberger et coll., 1994, or Kiddie SADS, Kiddie Schedule for Disorders and Schizophrenia for School Age Children, Orvaschel et coll., 1982): schizophrenia, addiction, bipolar disorder, recurrent depression (\> 2 episodes lifetime), severe, not stabilized anxiety disorder, history of episodes of epilepsy, significant inflammatory disease of immunosuppressive medication

Exclusion Criteria:

* for patients: ASD diagnosis not confirmed by assessments after the inclusion
* for all subjects: discovery of a counter indication to MRI during the exam (e.g. claustrophobia)

Where it's running

• APHP, Hôpital Robert Debré
  Paris, France Recruiting
• NeuroSpin neuroimaging platforme
  Gif-sur-Yvette, France Not yet recruiting

Study contacts

• Principal investigator: Richard Delorme, M.D, Ph.D — APHP, France
• Study coordinator: Richard Delorme, M.D, Ph.D
• Email: richard.delorme@aphp.fr
• Phone: +33140032002

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.