Clinical trial Recruiting at 2 sites Interventional Ages 18 and up

Moon and Sun Brothers — a community HIV prevention program for Spanish-speaking Latino men who have sex with men

Official title: Moon and Sun Brothers: A Community Prevention Intervention (Hermanos de Luna y Sol)

Run by San Francisco State University · NCT07475702 · Data updated 2026-11-12

This program tries group retreats, weekly discussions, community events, and counseling to see if they reduce sexual HIV risk and boost self‑esteem and social support for Spanish‑speaking Latino immigrant bisexual men and men who have sex with men.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment360 (estimated)
SponsorSan Francisco State University
Academic / other
Locations2 sites (San Francisco, California and 1 other locations)
StatusRecruiting
StartedJanuary 13, 2026
Main results expectedMarch 31, 2028
Study endsMarch 31, 2028
Registry record updatedMarch 25, 2026
Trial IDNCT07475702 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are Spanish‑speaking Latino/x/e men aged 18 or older who have had sex with men in the past year, live near San Francisco or Chicago, have access to a smartphone or computer, and are willing to join group activities.

Probably not a fit

People who are under 18, do not speak Spanish, do not have recent male sexual partners, or who already participated in the Hermanos de Luna y Sol program are unlikely to benefit from joining this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This quasi-experimental community intervention compares participants who receive a multi-component program with control participants who do not receive activities. Intervention components include an eight-hour group retreat, weekly discussion groups, community events and civic engagement, and prevention counseling delivered in Spanish. Outcomes include sexual risk behaviors (including condomless sex and PrEP use), help-seeking behavior, self‑esteem, and social support, with analyses testing whether self‑esteem and social support mediate effects on sexual risk. The study enrolls Spanish-speaking Latino/x/e men aged 18+ in San Francisco and Chicago who have had sex with men in the past year.

Why it matters

Potential benefit: If successful, the program could lower sexual HIV risk and strengthen self‑esteem and social support among Latino immigrant men, potentially reducing new infections and improving overall well‑being.

How similar studies have gone: Prior community-based, peer-group HIV prevention programs for Latino MSM have shown some success in reducing risk behaviors, but effects vary and this particular multi-component model combining retreats, civic engagement, and counseling is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Identify as male.
* Latino/x/e
* Report having sex with men only, or both men and women in the last 12 months.
* Speaks, reads/writes in Spanish.
* ≥18 years of age.
* Has access to a computer, laptop, tablet or smart phone device.
* Be willing to participate in the study.
* Be able to provide informed consent.

Exclusion Criteria:

* Populations younger than 18 years.
* Individuals who have participated in an Hermanos de Luna y Sol program in either the intervention or control group locations.

Where it's running

  • San Francisco State University
    San Francisco, California, United States
    Recruiting
  • Chicago Queer Latine Collaborative
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.