Monitoring spinal cord health in patients with multiple sclerosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to collect spinal cord MRI data from recently diagnosed patients with relapsing-remitting multiple sclerosis who are starting disease-modifying therapy. The research will investigate the incidence of asymptomatic spinal cord lesions and their impact on disease progression, particularly in patients who do not show brain MRI activity. By identifying these lesions, the study seeks to enhance understanding of disease activity and improve monitoring strategies for MS patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients between 18 and 65 years old
* Patients diagnosed with relapsing-remitting MS (≤5 years of first clinical event)
* Treatment-naïve patients starting (currently in the Netherlands approved) DMT

Exclusion Criteria:

* Patients who presented first clinical event more than five years ago
* Patients who have already started DMT
* Patients who are incapable of giving informed consent
* Patients who are unable to undergo local MRI scan, due to for instance
* Physical problems, for instance due to size/obesity (not fitting in regular MRI scanner), not being able to lie flat for extended periods of time (e.g. due to pain, shortness of breath)
* Due to claustrophobia
* Patients who have contraindications for MRI scan, for instance
* Due to MRI-unsafe or non-compatible implanted material/devices, such as pacemakers or ocular metal splinters
* Patients who are pregnant at inclusion

Where it's running

• Zuyderland Medisch Centrum
  Geleen, Limburg, Netherlands Recruiting
• Albert Schweitzer ziekenhuis
  Dordrecht, South Holland, Netherlands Recruiting
• Rijnstate
  Arnhem, Gelderland, Netherlands Not yet recruiting
• Jeroen Bosch Ziekenhuis
  's-Hertogenbosch, North Brabant, Netherlands Not yet recruiting
• Erasmus MC
  Rotterdam, South Holland, Netherlands Not yet recruiting

Study contacts

• Study coordinator: Demmie Bouweriks, MD
• Email: d.bouweriks@zuyderland.nl
• Phone: +31884597603

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.