Monitoring respiratory variability to guide high-flow oxygen in acute hypoxemic respiratory failure
Official title: Description of Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy - Exploratory Study
Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT06675045 · Data updated 2026-11-12
We’re testing whether watching how a patient’s breathing varies can help doctors decide when to continue high-flow oxygen or switch to invasive ventilation in adults with acute hypoxemic respiratory failure.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | GCS Ramsay Santé pour l'Enseignement et la Recherche Academic / other |
| Locations | 1 site (Marseille) |
| Status | Recruiting |
| Started | February 2, 2026 |
| Main results expected | October 31, 2027 |
| Study ends | October 31, 2027 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT06675045 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with acute hypoxemic respiratory failure treated with high-flow oxygen therapy.
✕Probably not a fit
Patients who do not exhibit actionable respiratory variability patterns or who rapidly improve with high-flow oxygen may not see a benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study focuses on respiratory variability monitoring in adults with acute hypoxemic respiratory failure who are treated with high-flow oxygen therapy. The goal is to help clinicians decide the optimal timing for possible intubation by identifying patterns in breathing variability. The study does not use a traditional drug therapy but relies on physiological monitoring to inform care.
Why it matters
Potential benefit: If successful, the approach could improve decisions about when to intubate, potentially reducing unnecessary intubations and timing delays.
How similar studies have gone: Previous work suggests that monitoring respiratory variables can inform ventilation decisions, but direct trials in this specific context are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient, male or female, aged ≥ 18 years * Patient admitted to intensive care with acute hypoxaemic respiratory failure * Patient treated with high-flow oxygen therapy Exclusion Criteria: * Patient admitted to intensive care with invasive ventilation * Patient with therapeutic abstention for intubation * Pregnant or breast-feeding women
Where it's running
-
Hôpital Privé Clairval
Marseille, France Recruiting
Study contacts
- Principal investigator: Kais BEN HASSEN, MD — Hôpital privé de Clairval
- Study coordinator: Kais BEN HASSEN, MD
- Email: kais.benhassen@gmail.com
- Phone: +33491171421
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.