Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Monitoring respiratory variability to guide high-flow oxygen in acute hypoxemic respiratory failure

Official title: Description of Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen Therapy - Exploratory Study

Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT06675045 · Data updated 2026-11-12

We’re testing whether watching how a patient’s breathing varies can help doctors decide when to continue high-flow oxygen or switch to invasive ventilation in adults with acute hypoxemic respiratory failure.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorGCS Ramsay Santé pour l'Enseignement et la Recherche
Academic / other
Locations1 site (Marseille)
StatusRecruiting
StartedFebruary 2, 2026
Main results expectedOctober 31, 2027
Study endsOctober 31, 2027
Registry record updatedAugust 20, 2026
Trial IDNCT06675045 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) with acute hypoxemic respiratory failure treated with high-flow oxygen therapy.

Probably not a fit

Patients who do not exhibit actionable respiratory variability patterns or who rapidly improve with high-flow oxygen may not see a benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study focuses on respiratory variability monitoring in adults with acute hypoxemic respiratory failure who are treated with high-flow oxygen therapy. The goal is to help clinicians decide the optimal timing for possible intubation by identifying patterns in breathing variability. The study does not use a traditional drug therapy but relies on physiological monitoring to inform care.

Why it matters

Potential benefit: If successful, the approach could improve decisions about when to intubate, potentially reducing unnecessary intubations and timing delays.

How similar studies have gone: Previous work suggests that monitoring respiratory variables can inform ventilation decisions, but direct trials in this specific context are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient, male or female, aged ≥ 18 years
* Patient admitted to intensive care with acute hypoxaemic respiratory failure
* Patient treated with high-flow oxygen therapy

Exclusion Criteria:

* Patient admitted to intensive care with invasive ventilation
* Patient with therapeutic abstention for intubation
* Pregnant or breast-feeding women

Where it's running

  • Hôpital Privé Clairval
    Marseille, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.