Monitoring minimal residual disease in patients with stage III non-small cell lung cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the significance of monitoring minimal residual disease (MRD) in patients with potentially resectable stage III non-small cell lung cancer (NSCLC) who do not have EGFR or ALK mutations. A total of 65 patients will be enrolled, and their peripheral blood samples will be collected at various stages, including after neoadjuvant therapy, surgery, and during follow-up. The study will utilize high-throughput sequencing to analyze ctDNA and evaluate the risk of cancer recurrence over a follow-up period of two years. The goal is to explore the potential of MRD biomarkers in predicting patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Capable of giving signed informed consent, age ≥ 18 and ≤ 80.
2. patients with stage Ⅲ non-small cell lung cancer confirmed by histology or cytology have potential surgical opportunities.
3. No driving gene EGFR/ALK mutation.
4. PS = 0-1.
5. the treatment process cooperated with the provision of clinicopathological and imaging data needed in the research process, followed up and collected the blood of the clinical efficacy evaluation nodes, and agreed to use the test data for follow-up research and product development.

Exclusion Criteria:

1. patients suffering from other malignant tumors.
2. patients change the treatment regimen before receiving the specified treatment or before the disease progresses.
3. Patients could not cooperate with the study for follow-up according to the defined clinical follow-up period;
4. Patients were unable to accept or provide imaging and other designated therapeutic evaluation means.

Where it's running

• Yuyan Wang
  Beijing, China Recruiting

Study contacts

• Principal investigator: Yuyan Wang, doctorate — Peking University Cancer Hospital & Institute
• Study coordinator: Yuyan Wang
• Email: wangyuyan1219@aliyun.com
• Phone: 010-88196497

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.