Monitoring microcirculation during major abdominal surgery
Evaluation of Perioperative Glycocalyx Monitoring in Major Abdominal Surgery
This study is testing a new way to monitor tiny blood flow in patients during major abdominal surgeries to see if it can help improve their care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | University Hospital, Rouen Academic / other |
| Locations | 1 site (Rouen) |
| Trial ID | NCT06285526 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on the real-time monitoring of microcirculation and glycocalyx in patients undergoing major abdominal surgeries, such as cytoreduction surgery with hyperthermic intraperitoneal chemotherapy and cephalic duodenopancreatectomy. Using the non-invasive GlycoCheck™ micro-camera, the study aims to enhance the understanding of microcirculatory dynamics, which could improve anesthesia and resuscitation strategies. By analyzing sublingual microcirculation, the research seeks to provide insights that go beyond traditional macro-circulatory parameters.
Who should consider this trial
Good fit: Ideal candidates include adult patients under 75 years old undergoing hyperthermic intraperitoneal chemotherapy or cephalic duodenopancreatectomy for specific conditions.
Not a fit: Patients with secondary distant peritoneal metastases, chronic organ failures, or those with injuries affecting sublingual microcirculation may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved patient outcomes by optimizing anesthesia and resuscitation techniques during major abdominal surgeries.
How similar studies have performed: While the approach of monitoring microcirculation is gaining interest, this specific application using the GlycoCheck™ device is relatively novel and has not been extensively tested in similar studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: For the HIPEC group : * Adult patients * Age \< 75 years * Receiving HIPEC for primary or secondary peritoneal carcinosis For the CDP group : * Adult patient * Age \< 75 years * Receiving CDP for pancreatic neoplasia * Patient who has read and understood the information letter and does not object to taking part in the study * Patient affiliated to a social security scheme Exclusion Criteria: * Secondary distant peritoneal metastases * Chronic heart failure * Chronic liver failure at stage C of the Child-Pugh score * Stage IV or V chronic renal failure * Inflammation of the sublingual buccal mucosa or injury that may locally influence sublingual microcirculation * Patient refusal * Person deprived of liberty by an administrative or judicial decision or person placed under court protection or guardianship
Where this trial is running
Rouen
- Rouen University Hospital — Rouen, France (Recruiting)
Study contacts
- Principal investigator: Zoé DEMAILLY, Dr — University Rouen Hospital
- Study coordinator: Zoé DEMAILLY, Dr
- Email: Zoe.Demailly@chu-rouen.fr
- Phone: 02 32 88 24 40
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.