Monitoring lung function in ARDS patients using electrical impedance tomography

Early Prone Positioning Monitored by Electrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome

This study tests if using a special monitoring tool can help doctors adjust breathing machines for patients with ARDS to improve their oxygen levels while keeping their lungs safe.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: Beijing Chao Yang Hospital (Academic / other)
• Locations: 1 site (Beijing, Beijing Municipality)
• Trial ID: NCT05822869 on ClinicalTrials.gov

What this trial studies

This clinical trial investigates the use of electrical impedance tomography (EIT) to guide mechanical ventilation strategies in patients with Acute Respiratory Distress Syndrome (ARDS). The study aims to improve oxygenation by utilizing prone position ventilation, which enhances ventilation to the dorsal lung regions. Participants will be monitored using EIT technology to adjust ventilator parameters effectively while maintaining lung-protective ventilation strategies. The trial focuses on patients who have been intubated for less than 36 hours and have specific oxygenation criteria.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who meet the diagnostic criteria for ARDS and have been intubated for less than 36 hours.

Not a fit: Patients who have contraindications to the prone position or EIT, or those who have received extracorporeal membrane oxygenation treatment, may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly improve oxygenation and reduce mortality rates in ARDS patients.

How similar studies have performed: Other studies have shown promising results with prone position ventilation in ARDS, but the use of EIT for monitoring in this context is relatively novel.

Eligibility criteria

Inclusion Criteria:

1. Age ≥ 18 years old；
2. Meets the diagnostic criteria for ARDS according to the 2012 Berlin definition；
3. Intubation with invasive mechanical ventilation time \< 36 hours；
4. PaO2/FiO2 \< 150mmHg.

Exclusion Criteria:

1. Contraindication to the prone position;
2. Contraindication to the EIT;
3. Patients have received extracorporeal membrane oxygenation treatment.

Where this trial is running

Beijing, Beijing Municipality

• Beijing Chao-Yang Hospital — Beijing, Beijing Municipality, China (Recruiting)

Study contacts

• Study coordinator: Yu Zhao, Dr.

Conditions Acute Respiratory Distress Syndrome; acute respiratory distress syndrome, prone position, electrical impedance tomography, mechanical ventilation