Monitoring heart rate variability in patients undergoing major surgery

Monitoring Functional Capacity Through Heart Rate Variability Within the Multimodal Rehabilitation Program in Adult Surgery

Observational Investigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon · NCT06436417

This study is testing if monitoring heart rate changes can help doctors understand how ready patients are for major surgery and improve their recovery.

Quick facts

Study typeObservational
Enrollment490 (estimated)
Ages18 Years and up
SexAll
SponsorInvestigation Group Anesthesia, Resuscitation, And Perioperative Medicine of Aragon Research network
Locations1 site (Zaragoza)
Trial IDNCT06436417 on ClinicalTrials.gov

What this trial studies

This observational cohort study investigates the use of heart rate variability (HRV) monitoring through the Analgesia Nociception Index (ANI) in adult patients scheduled for major surgery as part of a multimodal rehabilitation program. The study aims to correlate HRV indices with functional capacity, physiological reserve, and frailty during the prehabilitation phase. HRV will be assessed at two key points: during the initial pre-anesthesia consultation and one week prior to surgery, with results compared to various functional and frailty assessments.

Who should consider this trial

Good fit: Ideal candidates include adults over 18 years scheduled for major surgery who can provide informed consent.

Not a fit: Patients requiring urgent surgery, those with severe cognitive impairment, or those with cardiac arrhythmias may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance preoperative care by optimizing patient rehabilitation and reducing postoperative complications.

How similar studies have performed: While the use of HRV monitoring in surgical settings is emerging, this specific approach within a multimodal rehabilitation context is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients over 18 years of age
* Scheduled for major adult surgery
* Any ASA classification
* Signed informed consent

Exclusion Criteria:

* Urgent surgery
* Severe cognitive impairment
* Patient refusal to participate
* Pediatric patients
* Cardiac arrhythmia or atrial fibrillation

Where this trial is running

Zaragoza

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Frailty in Adult SurgeryHeart rate variability, prehabilitation, major surgery, frailty, physiological reserve
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.