Molecular biomarkers in women with cervical cancer
Official title: Phase 0 Clinical Trial of Molecular Biomarkers in Women With Uterine Cervix Cancer
Run by University of Kentucky · NCT05462951 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is trying to find specific markers in the blood of women with advanced cervical cancer to better understand how the disease progresses and responds to treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | Women only |
| Enrollment | 30 (estimated) |
| Sponsor | University of Kentucky Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Lexington, Kentucky) |
| Trial ID | NCT05462951 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are women with untreated stage IB3, II, III, or IVA cervical cancer who are not eligible for curative surgery.
✕Probably not a fit
Patients with concurrent active invasive malignancies or those who have had prior pelvic radiotherapy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational clinical trial focuses on women diagnosed with advanced uterine cervix cancer who will receive standard-of-care radiochemotherapy followed by brachytherapy. Blood samples will be collected to analyze circulating levels of deoxyribonucleotides, human papillomavirus DNA, and circulating tumor cells, aiming to identify molecular biomarkers associated with the disease. The study seeks to enhance understanding of the disease's progression and treatment response through these biomarkers.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and treatment strategies for women with cervical cancer.
How similar studies have gone: Other studies have explored molecular biomarkers in cancer treatment, showing promising results, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: - Untreated pathologically or cytologically-confirmed diagnosis of stage IB3 (\> 4cm), II, III, or IVA (FIGO 2018) squamous, adenosquamous, or adenocarcinoma of the uterine cervix not amenable to curative surgery alone. Exclusion Criteria: * Presence of another concurrent active invasive malignancy * Prior invasive malignancy diagnosed within the last three years except for \[1\] non-melanoma skin cancer or \[2\] prior in situ carcinoma of the cervix * prior pelvic radiotherapy for any reason that would contribute radiation dose that would exceed tolerance of normal tissues at the discretion of the treating physician.
Where it's running
-
Markey Cancer Center
Lexington, Kentucky, United States Recruiting
Study contacts
- Principal investigator: Denise Fabian, MD — University of Kentucky
- Study coordinator: Yvonne Taul
- Email: yvonne.taul@uky.edu
- Phone: 859-323-2354
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Short-course radiation with chemotherapy for cervical cancer
This trial will test whether a shorter, higher-dose pelvic radiation schedule given with cisplatin and followed by brachytherapy helps women with bulky or limited-metastatic cervical cancer.
-
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This study looks at how well people with head and neck cancer stick to their swallowing exercises after radiation treatment and what factors might help or hinder them.
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Examining the link between physical activity and survival in advanced cancer patients
This study is testing how physical activity affects survival and overall health in people with advanced cancer by using wearable devices to track their activity levels.
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Shorter pelvic radiotherapy after surgery for cervical or endometrial cancer
A randomized study tests whether a shorter course of postoperative whole-pelvic radiotherapy can be as safe and effective as the standard longer schedule for women with cervical or endometrial cancer.
-
Late radiation side effects after postoperative IMRT and brachytherapy for cervical and endometrial cancer
This project will see how often and how severe late gastrointestinal and urinary side effects are in people with cervical or endometrial cancer who received postoperative IMRT and/or brachytherapy at Tata Memorial Hospital.
-
Comparing clinic-only versus clinic plus community outreach to offer HPV self-collection for cervical screening in women with HIV
This project will test whether adding community health worker outreach to clinic services helps more women living with HIV complete HPV self-collection for cervical screening.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.