Modified VISTA gum-covering using albumin-PRF versus connective tissue graft for multiple Miller Class III gum recessions
Official title: Clinical Evaluation of the Modified VISTA Technique (M-VISTA )Using Albumin-platelet Rich Fibrin (Alb-PRF) Versus Connective Tissue Graft (CTG)in the Treatment of Multiple Miler Class III RT2 Recessions A Randomized Clinical Trial
Run by Cairo University · NCT06643507 · Data updated 2026-11-12
This test tries to see whether a modified VISTA gum-covering technique using albumin-PRF works as well as the standard connective tissue graft for adults with multiple Miller Class III (RT2) gum recessions who have good oral hygiene.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 26 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Status | Recruiting |
| Started | April 20, 2025 |
| Main results expected | December 20, 2026 |
| Study ends | January 30, 2027 |
| Registry record updated | March 20, 2026 |
| Trial ID | NCT06643507 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with multiple Miller Class III (RT2) gingival recessions and good oral hygiene who are non-smokers.
✕Probably not a fit
Smokers, people with poor oral hygiene, or those with different types of recession (non-RT2/Miller III) are unlikely to benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study compares a modified VISTA surgical approach using albumin-derived platelet-rich fibrin (ALB-PRF) to the conventional connective tissue graft for treating multiple Miller Class III (RT2) gingival recessions. Adults with good oral hygiene and multiple RT2 recessions will receive the modified VISTA technique with one of the two graft materials and be followed for clinical root-coverage outcomes. Primary outcomes include percentage of root coverage and soft tissue thickness, while secondary outcomes include wound healing and donor-site morbidity. The trial is conducted at the Faculty of Dentistry, Cairo University under phase 2/3 protocols to compare safety and effectiveness.
Why it matters
Potential benefit: If successful, this could offer similar root coverage with less donor-site morbidity and a simpler graft material using albumin-PRF.
How similar studies have gone: Connective tissue grafting is the established gold standard for root coverage, while PRF-based approaches including albumin-PRF have shown promising but limited comparative data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18 years old good oral hygiene Exclusion Criteria: * smokers patients with poor oral hygiene
Where it's running
-
Faculty of Dentistry Cairo University
Cairo, Egypt Recruiting
Study contacts
- Study coordinator: Tamani TM Mahmoud, BDS.MDS
- Email: tamanni.mahmoud@dentistry.cu.edu.eg
- Phone: Egypt:+201017874915
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Root coverage using different restorative materials in Class V lesions
This study tests whether using glass ionomer cement, resin composite, or no restoration before root coverage surgery helps people with gum recession and neck lesions
-
Volume-stable collagen matrix vs graft for multiple gingival recessions
This study tests whether a volume-stable collagen matrix can cover exposed roots as well as a traditional graft, in adults with multiple gingival recessions.
-
Gingival recession and its effect on oral health-related quality of life
This project will see how common gingival recession is and whether it affects oral health-related quality of life in adults aged 18–45 who visit a tertiary dental center in Haryana.
-
Comparing a new 3D tunneling technique with a modified coronally advanced tunnel plus connective tissue graft for treating multiple RT2 gingival recession.
This trial will try a new 3D tunneling surgical technique versus a modified coronally advanced tunnel with connective tissue graft to improve root coverage in adults who have multiple RT2 gingival recessions.
-
Using 3D dental imaging to lower gum recession during aligner treatment
This test tries to see if planning aligner treatment with 3D CBCT imaging instead of 2D images can reduce gum recession for adults undergoing dental arch expansion.
-
Gum recession in adults with and without prior orthodontic treatment
We will test which patient and tooth factors increase the chance of gum recession in adults who have or have not had orthodontic treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.