Clinical trial Recruiting at 1 site Phase2; Phase3 Interventional Ages 18 to 60

Modified VISTA gum-covering using albumin-PRF versus connective tissue graft for multiple Miller Class III gum recessions

Official title: Clinical Evaluation of the Modified VISTA Technique (M-VISTA )Using Albumin-platelet Rich Fibrin (Alb-PRF) Versus Connective Tissue Graft (CTG)in the Treatment of Multiple Miler Class III RT2 Recessions A Randomized Clinical Trial

Run by Cairo University · NCT06643507 · Data updated 2026-11-12

This test tries to see whether a modified VISTA gum-covering technique using albumin-PRF works as well as the standard connective tissue graft for adults with multiple Miller Class III (RT2) gum recessions who have good oral hygiene.

More Gingival Recession trials

Quick facts

PhasePhase2; Phase3
Study typeInterventional
Ages18 Years to 60 Years
SexAll
Enrollment26 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedApril 20, 2025
Main results expectedDecember 20, 2026
Study endsJanuary 30, 2027
Registry record updatedMarch 20, 2026
Trial IDNCT06643507 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older with multiple Miller Class III (RT2) gingival recessions and good oral hygiene who are non-smokers.

Probably not a fit

Smokers, people with poor oral hygiene, or those with different types of recession (non-RT2/Miller III) are unlikely to benefit from this approach.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study compares a modified VISTA surgical approach using albumin-derived platelet-rich fibrin (ALB-PRF) to the conventional connective tissue graft for treating multiple Miller Class III (RT2) gingival recessions. Adults with good oral hygiene and multiple RT2 recessions will receive the modified VISTA technique with one of the two graft materials and be followed for clinical root-coverage outcomes. Primary outcomes include percentage of root coverage and soft tissue thickness, while secondary outcomes include wound healing and donor-site morbidity. The trial is conducted at the Faculty of Dentistry, Cairo University under phase 2/3 protocols to compare safety and effectiveness.

Why it matters

Potential benefit: If successful, this could offer similar root coverage with less donor-site morbidity and a simpler graft material using albumin-PRF.

How similar studies have gone: Connective tissue grafting is the established gold standard for root coverage, while PRF-based approaches including albumin-PRF have shown promising but limited comparative data.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 18 years old good oral hygiene

Exclusion Criteria:

* smokers patients with poor oral hygiene

Where it's running

  • Faculty of Dentistry Cairo University
    Cairo, Egypt
    Recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.