Mobile HPV testing versus centralized screening to prevent cervical cancer in women living with HIV in western Cameroon

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares two delivery approaches for cervical cancer screening among women living with HIV: a decentralized mobile unit offering quasi point-of-care HPV testing with immediate visual triage and same-day treatment when needed, versus referral to centralized, well-equipped screening centers. Women aged 25–49 on or starting antiretroviral therapy who consent will be enrolled and offered one of the approaches at participating sites in the Western Region of Cameroon. Key outcomes include screening uptake, completion of the screen-to-treatment sequence, loss to follow-up at each step, and measures of cost and quality. The results aim to show which approach improves coverage and reduces dropouts in real-world, resource-limited clinic settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women
* HIV infection
* Age between 25 and 49 years old
* Receiving or starting ARV treatment
* Agreeing to participate in the study and having signed the consent

Exclusion Criteria:

* Current pregnancy
* Hysterectomy
* Treatment of cervical lesions within 12 months
* Expected follow-up difficulties: planned absence that could interfere with the participation in the study (e.g., travel abroad, relocation, imminent transfer, etc.);
* Any pathology or concomitant treatment which, in the opinion of the investigators, contraindicates participation or prevents satisfactory participation in the study

Deferred inclusion if

* menstrual bleeding
* Postpartum (\<12 weeks after delivery)
* Clinical signs of cervical or pelvic infection

Where it's running

• Bafoussam Baptist Hospital
  Bafoussam, Cameroon Recruiting
• Bingo Hospital
  Bafoussam, Cameroon Recruiting
• Centre Médical Spécialisé ACHA
  Bafoussam, Cameroon Recruiting
• Hôpital Régional Annexe
  Bafoussam, Cameroon Recruiting
• Bandjoun District Hospital
  Bandjoun, Cameroon Recruiting
• Foumbot District Hospital
  Foumbot, Cameroon Recruiting

Study contacts

• Principal investigator: Joëlle Sobngwi, MD, PhD — RSD Institute
• Study coordinator: Andre-Pascal Goura, MD
• Email: cdpoptitri@gmail.com
• Phone: +227679336464

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Single-visit versus multiple-visit cervical cancer screen-and-treat for women with HIV in Foumban, Cameroon

  This project will test whether doing all cervical cancer screening and treatment in one clinic visit or spreading it over multiple visits helps more women living with HIV complete care.

  Recruiting Institut de Recherche pour le Developpement · Foumban · NCT07177170

• Home-based cervical cancer self-sampling with education for women living with HIV in Ghana

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  Recruiting Baylor University · Cape Coast, Central Region · NCT06800664

• Risk of cervical cancer after HPV detection in healthy women

  This study tests how likely it is for cervical cancer to develop after different HPV detection patterns in healthy women who undergo HPV-based screening.

  Recruiting Karolinska Institutet · Stockholm · NCT07850128

• Routine shallow-coverage Whole Genome Sequencing of Cervical Smears to See if Ovarian Cancer is Found Earlier

  Researchers test whether analyzing DNA from cervical smears with shallow whole-genome sequencing can help detect high-grade serous ovarian cancer early in patients undergoing treatment for this cancer.

  Recruiting Institut Claudius Regaud · Toulouse · NCT07821879

• Project SHIELD 2.0: Police Education to Support Public Health in Kentucky

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  Recruiting Johns Hopkins Bloomberg School of Public Health · Lexington, Kentucky · NCT07804121

• New ways to diagnose lymphoma and multicentric Castleman disease in people living with HIV

  This study tests a quick, point-of-care nucleic acid test to help diagnose lymphoma and multicentric Castleman disease in people living with HIV in sub-Saharan Africa.

  Recruiting Indiana University · Lilongwe · NCT07793006

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.