MitoQ and ischemic conditioning to improve vascular health after stroke

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this Phase 2 interventional trial, adults with chronic cortical or subcortical stroke and residual hemiparesis will receive a single bout of ischemic conditioning or oral MitoQ supplementation to examine effects on vascular function. Researchers will measure outcomes such as flow-mediated dilation, microvascular blood flow, and muscle activity before and after the interventions. The protocol targets safety and short-term physiological changes that might underlie improved exercise tolerance and lower secondary cardiovascular risk. The study is conducted at the Medical College of Wisconsin and focuses on objective vascular measures rather than clinical recovery endpoints.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 - 85 years of age
* Cortical or sub-cortical stroke ≥ 6 months ago with residual hemiparesis
* Able to give informed consent and follow 2-step command.
* English Speaking

Exclusion Criteria:

* Unable to stand from chair without physical assistance from another person (able to use assistive device).
* History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (i.e., wounds in the leg).
* Chronic lasting symptoms (\> 6 months) of severe COVID-19 (i.e., hospitalization)
* History of head trauma or concussion within the past 6 months
* Comorbid neurological disorder
* Peripheral vascular disease
* Myocardial infarction or arrhythmia in the previous year
* Resting SBP ≥180 mmHg or DBP ≥ 100 mmHg
* Pregnant or breastfeeding.
* Other significant medical condition likely to influence study or jeopardize safety as assessed by the Primary Investigator

Where it's running

• Medical College of Wisconsin
  Milwaukee, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Matthew Durand, PhD — Medical College of Wisconsin
• Study coordinator: Jennifer Nguyen
• Email: jnguyen@mcw.edu
• Phone: 414-955-5713

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.