Misoprostol versus watchful waiting for retained tissue after first-trimester medical abortion
Official title: The Success Rate After Expectant & Medical Management for a Retained Product of Conception After Medical Termination of Pregnancy in First Trimester Spontaneous Abortion-RCT
Run by Meir Medical Center · NCT07534982 · Data updated 2026-11-12
This project will test whether taking misoprostol or simply watching and waiting works better to clear retained tissue after a first‑trimester medical abortion in women aged 18–45 with ultrasound evidence of retained products.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | Women only |
| Enrollment | 150 (estimated) |
| Sponsor | Meir Medical Center Academic / other |
| Locations | 1 site (Kfar Saba) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | July 1, 2027 |
| Study ends | July 1, 2027 |
| Registry record updated | April 16, 2026 |
| Trial ID | NCT07534982 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Women aged 18–45 who are hemodynamically stable after a first‑trimester medical abortion, have sonographic RPOC defined as endometrial thickness >10 mm with Doppler flow, bleeding similar to a menstrual period, and no fever.
✕Probably not a fit
Women with heavy bleeding, fever, hemodynamic instability, endometrial thickness >40 mm, a retained gestational sac, or who have already received two doses of misoprostol are excluded and unlikely to benefit from these non‑surgical options.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective randomized controlled trial that assigns 150 women with sonographic evidence of retained products of conception (RPOC) after first‑trimester medical abortion to either medical management with misoprostol or expectant (watchful waiting) management. Eligible participants are hemodynamically stable women aged 18–45 with endometrial thickness >10 mm and Doppler flow into the uterine cavity. Participants will attend three follow‑up visits over six weeks with ultrasound monitoring to document uterine clearance and record complications. Primary outcomes include radiographic resolution of RPOC and need for surgical intervention, with secondary safety and complication endpoints.
Why it matters
Potential benefit: If successful, this approach could reduce the need for surgical removal and offer a safe non‑surgical option for many women with RPOC.
How similar studies have gone: Previous studies and clinical experience show misoprostol can resolve RPOC in many patients and expectant management succeeds for some, but randomized comparisons are limited and results have varied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 18-45. 2. RPOC identified on ultrasound after medical abortion, defined as endometrial thickness \>10 mm with Doppler flow into the uterine cavity. 3. Hemodynamically stable women with bleeding comparable to menstrual flow, without fever. Exclusion Criteria: 1. Hemodynamic instability, excessive bleeding, or fever. 2. Endometrial thickness \>40 mm. 3. Endometrial thickness \<10 mm without Doppler flow into the cavity. 4. Presence of a gestational sac within the uterine cavity. 5. Women who received two doses of misoprostol before evaluation.
Where it's running
-
Meir Medical Center
Kfar Saba, Israel Recruiting
Study contacts
- Study coordinator: Chen Manor Bar, MD
- Email: Manor.chen@gmail.com
- Phone: +972544414211
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.