Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Mirror therapy vs CO-OP vs conventional occupational therapy with robotic balance training for stroke recovery

Official title: Comparative Effects of Mirror Therapy, Cognitive Orientation to Daily Occupational Performance, and Conventional Occupational Therapy in Individuals With Stroke: A 3-Month Follow-Up Randomized Controlled Trial

Run by Hacettepe University · NCT07546864 · Data updated 2026-11-12

This project will try three rehab approaches—mirror therapy, CO-OP, and conventional occupational therapy—each paired with robotic balance training, to see which helps adults 3–12 months after stroke improve movement, daily activities, and quality of life.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment45 (estimated)
SponsorHacettepe University
Academic / other
Locations1 site (Bayburt, Merkez)
StatusRecruiting
StartedFebruary 15, 2026
Main results expectedMay 15, 2026
Study endsJune 15, 2027
Registry record updatedApril 23, 2026
Trial IDNCT07546864 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18 years) with ischemic or hemorrhagic stroke in the subacute (3–6 months) or chronic (6–12 months) phase who meet motor function thresholds (Brunnstrom stages) and cognitive screening (MMSE ≥24) without severe visual, orthopedic, or additional neurologic impairments are ideal candidates.

Probably not a fit

Patients with major medical problems or poor motor coordination, Wernicke's aphasia, recent botulinum toxin injections, severe psychiatric conditions, or significant cognitive impairment are unlikely to benefit or be eligible for participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a randomized controlled design, 45 adults with subacute or chronic stroke will be assigned to one of three groups receiving either mirror therapy (MT), Cognitive Orientation to Daily Occupational Performance (CO-OP), or conventional occupational therapy (COT), with all groups receiving robotic balance training as a priming intervention. Interventions run 4 weeks at five sessions per week, and a transfer package is used to promote generalization to daily life. Outcomes include motor and somatosensory function, occupational performance, activities of daily living, participation, self-efficacy, and quality of life measured at baseline, immediately post-intervention, and at a 3-month follow-up. The trial compares the relative effectiveness of these approaches to guide clinical decision-making for stroke rehabilitation.

Why it matters

Potential benefit: If successful, this approach could identify a more effective therapy combination to improve motor recovery, daily function, and quality of life after stroke.

How similar studies have gone: Prior studies have shown benefits of mirror therapy and CO-OP for motor and functional gains after stroke, but direct head-to-head comparisons combined with robotic balance priming are limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* \- Individuals diagnosed with ischemic or hemorrhagic stroke
* Age 18 years and older
* Subacute (3-6 months post-stroke) or chronic stage (6-12 months post-stroke)
* Brunnstrom Motor Recovery Stage ≥3 for upper extremity, ≥4 for hand, and ≥4 for lower extremity
* Mini-Mental State Examination (MMSE) score ≥24
* No severe visual, orthopedic, or additional neurological impairments
* Not participating in another study during the research period
* Voluntary consent to participate in the study

Exclusion Criteria:

* \- Poor motor coordination or major medical problems that would prevent participation
* Presence of Wernicke's aphasia
* Botulinum toxin injection within the last 3 months
* Psychiatric conditions that may interfere with participation (e.g., depression, ongoing psychiatric treatment, low motivation)

Where it's running

  • Bayburt State Hospital
    Bayburt, Merkez, Turkey (Türkiye)
    Recruiting

Study contacts

  • Principal investigator: Gokcen Akyurek, Associate Professor — Hacettepe University
  • Study coordinator: NURTEN BİLGİN, PhD Student
  • Email: nurtenncek@gmail.com
  • Phone: +905546366542

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.