Mirogabalin for pain relief in people with herpes zoster

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, controlled comparison adds mirogabalin to conventional antiviral and analgesic therapy versus conventional therapy alone for adults with acute herpes zoster pain. Eligible participants are adults within 30 days of rash onset who report moderate-to-severe pain (NRS ≥4) and have adequate liver and kidney function; those with prior gabapentin/pregabalin use or disseminated/ocular HZ are excluded. Pain intensity and safety outcomes will be tracked during the treatment period to see if mirogabalin provides stronger analgesia with acceptable tolerability. The trial is led by Beijing Tiantan Hospital with collaboration from regional university hospitals and requires site visits in Beijing.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Ages more than 18 years;
* 2\. Patients with onset of HZ rash less than 30 days;
* 3\. Experiencing moderate to severe HZ pain with an average pain score of at least 4 on a Numeric Rating Scale (NRS, 0 = no pain, 10 = worst possible pain);
* 4\. Aspartate aminotransferase and alanine aminotransferase levels less than twice the upper limit of normal;
* 5\. Estimated glomerular filtration rate of 30 mL/min per 1.73 m2 or higher;
* 6\. Willing to sign the informed consent form and possessing sufficient cognitive and language abilities to comply with all the study requirements.

Exclusion Criteria:

* 1\. History of taking gabapentin or pregabalin;
* 2\. Patients with evidence of cutaneous or visceral dissemination of HZ infection (cutaneous dissemination is defined as more than 20 discrete lesions outside adjacent dermatomes) or ocular involvement of HZ;
* 3\. History of intolerance or hypersensitivity to any active components or excipient of the mirogabalin;
* 4\. History of systemic immune diseases, organ transplantation, or cancers;
* 5\. Pregnancy or breastfeeding;
* 6\. Suffering from acute or chronic pain disorders other than HZ;
* 7\. Patients with severe psychiatric disorders, or cognitive impairment.

Where it's running

• Beijing Tiantan Hospital, Beijing, Beijing 100070
  Beijing, China Recruiting

Study contacts

• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: 13611326978

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.