Minocycline treatment for cystoid macular edema
Efficacy and Safety of the Treatment of Minocycline for Cystoid Macular Edema
PHASE1; PHASE2 · Sun Yat-sen University · NCT05474950
This study is testing if the antibiotic minocycline can help improve vision in people aged 18-60 with cystoid macular edema, a condition that can threaten eyesight.
Quick facts
| Phase | PHASE1; PHASE2 |
|---|---|
| Study type | Interventional |
| Enrollment | 5 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Sun Yat-sen University (other) |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT05474950 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the efficacy and safety of minocycline, a broad-spectrum antibiotic, for treating cystoid macular edema (CME), a sight-threatening condition. The study aims to determine how well minocycline can improve symptoms of CME, especially given the limitations of current treatments like anti-VEGF and glucocorticoids. Participants aged 18-60 diagnosed with CME will receive minocycline and be monitored for outcomes. The trial is designed to assess both the therapeutic effects and safety profile of this treatment.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18-60 who have been diagnosed with cystoid macular edema.
Not a fit: Patients with allergies to minocycline or tetracyclines, or those with significant organ dysfunction, may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new therapeutic option for patients suffering from cystoid macular edema.
How similar studies have performed: While the use of minocycline in this context is novel, its immunomodulatory properties have shown promise in other immune-related conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participant diagnosed with CME. * Participant aged from 18-60 years old. * Participant that signed the informed consent document and is able to complete the following visits. Exclusion Criteria: * Participant is allergy to minocycline or tetracyclines. * Participant has no contraindications of minocycline or tetracyclines. * Participant has an abnormal function of liver, heart, kidney and thyroid. * Female that is pregnant, breast-feeding or planning to become pregnant. * Participant that is currently using other medications.
Where this trial is running
Guangzhou, Guangdong
- Zhongshan Ophthalmic Center — Guangzhou, Guangdong, China (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Minocycline, Cystoid Macular Edema