Minimally invasive treatment for severe osteoporotic vertebral fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the outcomes of two minimally invasive procedures for treating very severe osteoporotic vertebral compression fractures in elderly patients. Participants are randomly assigned to either percutaneous vertebroplasty (PVP) or percutaneous vertebral-disc plasty (PVDP), with both techniques involving the injection of bone cement to stabilize the vertebrae. The study evaluates clinical outcomes and radiological parameters, including pain levels and spinal alignment, before and after the procedures. The aim is to determine which method provides better relief from back pain and improves spinal stability.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* bone mineral density T scores \<-2.5;
* compression of the vertebral anterior column greater than two-thirds of their original height;
* Kyphosis with LKA greater than 20°;
* the accordion phenomenon: the different angles of a supine CT scan and a lateral standing X-ray measurement;
* upper or lower vertebral endplate fracture;
* the involved vertebral body was intact;
* Elderly patients with a history of major illness (such as cardiovascular disease, cancer or active malignancy) and were intolerant of the traditional open surgery.

Exclusion Criteria:

* Pathological vertebral fractures caused by spinal tumors, spinal tuberculosis, and spinal infection and so on;
* Patients with symptoms of nerve roots or spinal cord compression;
* Patients with a previous history of spinal fusion;
* A history of abnormal bleeding or coagulation disorder dysfunction.

Where it's running

• Affiliated 2 Hospital of Nantong University
  Nantong, Jiangsu, China Recruiting

Study contacts

• Principal investigator: Guanhua Xu, Dr — Affiliated 2 Hospital of Nantong University
• Study coordinator: Jiawei Jiang, Dr
• Email: 18862802782@163.com
• Phone: 18862802782

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• VCFix Spinal System in vertebral compression fractures due to osteoporosis

  This study tests the VCFix Spinal System in real-world US patients with vertebral compression fractures from osteoporosis to see how it performs outside a controlled trial.

  Recruiting Amber Implants B.V. · New York, New York and 2 other locations · NCT07920484

• Assessing Osteosarcopenia in Patients with Hip Fractures

  This study is testing if certain tests can help identify muscle and bone issues in patients with hip fractures to improve their recovery after surgery.

  Recruiting Istituto Ortopedico Rizzoli · Bologna · NCT04730622

• Post-osteoporotic fracture exercise program

  Aimed at people with osteoporosis who recently had a fracture, the study tests group exercise classes to see if they are feasible and safe and could help bone health and physical function.

  Recruiting Western University, Canada · London, Ontario · NCT07595991

• MDW blood test to predict complications and survival after hip fracture

  This will test whether a routine blood measure called Monocyte Distribution Width (MDW) can help predict complications or death in people aged 65 and older who have a low-energy hip fracture.

  Recruiting National and Kapodistrian University of Athens · Kifissia, Attica · NCT07350785

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.