Minimally invasive treatment for knee osteoarthritis
Official title: Geniculate Artery Embolization for the Treatment of Knee Osteoarthritis
Run by University of Calgary · NCT05386797 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing a new, less invasive treatment for knee osteoarthritis to see if it can help people who haven't found relief from other therapies and want to avoid surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University of Calgary Academic / other |
| Locations | 1 site (Calgary) |
| Trial ID | NCT05386797 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals over 40 years old with knee pain resistant to conservative treatments and who are not surgical candidates.
✕Probably not a fit
Patients with severe knee osteoarthritis or those with significant comorbidities that contraindicate the procedure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the use of geniculate artery embolization (GAE) as a treatment for knee osteoarthritis, a common degenerative joint disease that causes chronic pain and disability. The study aims to provide a minimally invasive alternative for patients who have not responded to conservative therapies and are either not surgical candidates or prefer to avoid surgery. GAE works by disrupting the blood supply to the affected area, potentially alleviating pain and improving function. Participants will be monitored for pain relief and overall quality of life improvements following the procedure.
Why it matters
Potential benefit: If successful, this treatment could offer significant pain relief and improved quality of life for patients suffering from knee osteoarthritis.
How similar studies have gone: Preliminary studies on geniculate artery embolization have shown promise, suggesting that this approach may be effective, though it remains relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. VAS score of at least 50 mm for knee pain 2. Pain resistant to at least 3 months of conservative therapy (including medical therapy, physiotherapy, intra-articular cortisone or viscosupplement injection). 3. Age \> 40 years 4. Radiographs demonstrating knee osteoarthritis on same side as pain 5. Patient not a surgical candidate or declines surgical management Exclusion Criteria: 1. Radiographically severe knee osteoarthritis (Kellgren-Lawrence grade \>2) 2. Severe non-knee related lower limb pain with VAS \> 50 mm. 3. Local infection and inflammatory arthritis. 4. Malignancy 5. Previous knee surgery 6. Bleeding risk - known hematologic disease increasing risk of bleeding, pre-procedure INR \> 1.4, pre-procedure PTT \> 40 seconds or pre-procedure platelets \< 50,000/uL 7. Known chronic renal failure or eGFR \< 45 8. ECOG grade \> 2 9. Patient weight \> 300 lbs 10. Patient unreliable for follow up
Where it's running
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Foothills Hospital
Calgary, Canada Recruiting
Study contacts
- Study coordinator: Jason Wong, MD
- Email: wongjk@ucalgary.ca
- Phone: 403-944-1132
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.