Minimally invasive segmentectomy versus lobectomy for stage I lung cancer: recovery and quality of life
Official title: Living After Lung Surgery: Clinical Outcomes and Quality Of Life After Minimally Invasive Segmentectomy Versus Lobectomy for Lung Cancer
Run by Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · NCT07477158 · Data updated 2026-11-12
This test sees if people with stage I non-small cell lung cancer who have minimally invasive segmentectomy have less breathlessness and better quality of life in the first year after surgery than those who have lobectomy.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal Academic / other |
| Locations | 1 site (Madrid, Madrid) |
| Status | Recruiting |
| Started | July 10, 2023 |
| Main results expected | December 1, 2027 |
| Study ends | December 1, 2027 |
| Registry record updated | March 19, 2026 |
| Trial ID | NCT07477158 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with clinical stage I non-small cell lung cancer who are undergoing minimally invasive segmentectomy or lobectomy (VATS or RATS), have not had thoracic surgery in the past year, and have not received neoadjuvant therapy are the ideal candidates.
✕Probably not a fit
Patients with more advanced or unresectable disease, recent thoracic surgery, prior neoadjuvant therapy, or those unable to complete the required questionnaires are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational study collecting patient-reported outcomes before surgery and at multiple points during the first year after minimally invasive segmentectomy or lobectomy for stage I NSCLC. Participants complete questionnaires on dyspnea, physical function, and health-related quality of life, and outcomes after video-assisted (VATS) versus robotic-assisted (RATS) approaches are compared. Patients with recent thoracic surgery, neoadjuvant therapy, or who fail to complete baseline questionnaires are excluded. The study is conducted at Hospital Universitario Ramón y Cajal in Madrid and uses routine surgical care rather than experimental interventions.
Why it matters
Potential benefit: If successful, the findings could show that segmentectomy preserves breathing function and quality of life better than lobectomy, helping clinicians and patients choose a less disruptive operation when oncologically appropriate.
How similar studies have gone: Randomized trials (for example JCOG0802) have shown segmentectomy can preserve lung function and have comparable oncologic outcomes for small peripheral NSCLC, but focused patient-reported outcome comparisons remain limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with clinical stage I NSCLC who undergo segmentectomy or lobectomy with VATS or RATS. Exclusion Criteria: * Thoracic surgery in the previous year * Neoadyuvant treatment * Failure to complete preoperative questionnaires
Where it's running
-
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Spain Recruiting
Study contacts
- Principal investigator: Sara Fra, MD — Hospital Universitario Ramon y Cajal
- Study coordinator: Sara Fra, MD
- Email: sarafrafernandez@gmail.com
- Phone: 0034913369102
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.