Clinical trial Recruiting at 1 site Observational Ages 18 and up

Minimally invasive segmentectomy versus lobectomy for stage I lung cancer: recovery and quality of life

Official title: Living After Lung Surgery: Clinical Outcomes and Quality Of Life After Minimally Invasive Segmentectomy Versus Lobectomy for Lung Cancer

Run by Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal · NCT07477158 · Data updated 2026-11-12

This test sees if people with stage I non-small cell lung cancer who have minimally invasive segmentectomy have less breathlessness and better quality of life in the first year after surgery than those who have lobectomy.

More Non-Small Cell Lung Cancer trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment180 (estimated)
SponsorFundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Academic / other
Locations1 site (Madrid, Madrid)
StatusRecruiting
StartedJuly 10, 2023
Main results expectedDecember 1, 2027
Study endsDecember 1, 2027
Registry record updatedMarch 19, 2026
Trial IDNCT07477158 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with clinical stage I non-small cell lung cancer who are undergoing minimally invasive segmentectomy or lobectomy (VATS or RATS), have not had thoracic surgery in the past year, and have not received neoadjuvant therapy are the ideal candidates.

Probably not a fit

Patients with more advanced or unresectable disease, recent thoracic surgery, prior neoadjuvant therapy, or those unable to complete the required questionnaires are unlikely to benefit from participation.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational study collecting patient-reported outcomes before surgery and at multiple points during the first year after minimally invasive segmentectomy or lobectomy for stage I NSCLC. Participants complete questionnaires on dyspnea, physical function, and health-related quality of life, and outcomes after video-assisted (VATS) versus robotic-assisted (RATS) approaches are compared. Patients with recent thoracic surgery, neoadjuvant therapy, or who fail to complete baseline questionnaires are excluded. The study is conducted at Hospital Universitario Ramón y Cajal in Madrid and uses routine surgical care rather than experimental interventions.

Why it matters

Potential benefit: If successful, the findings could show that segmentectomy preserves breathing function and quality of life better than lobectomy, helping clinicians and patients choose a less disruptive operation when oncologically appropriate.

How similar studies have gone: Randomized trials (for example JCOG0802) have shown segmentectomy can preserve lung function and have comparable oncologic outcomes for small peripheral NSCLC, but focused patient-reported outcome comparisons remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients with clinical stage I NSCLC who undergo segmentectomy or lobectomy with VATS or RATS.

Exclusion Criteria:

* Thoracic surgery in the previous year
* Neoadyuvant treatment
* Failure to complete preoperative questionnaires

Where it's running

  • Hospital Universitario Ramón y Cajal
    Madrid, Madrid, Spain
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.