Clinical trial Recruiting at 1 site Interventional Ages 18 to 29

Mindful Self-Compassion program for transgender and nonbinary young adults

Official title: Evaluating the Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults

Run by University of Rhode Island · NCT06409975 · Data updated 2026-11-12

This 8-week online Mindful Self-Compassion program will be tried with transgender and nonbinary young adults to see if it is practical and acceptable.

Quick facts

Study typeInterventional
Ages18 Years to 29 Years
SexAll
Enrollment50 (estimated)
SponsorUniversity of Rhode Island
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Providence, Rhode Island)
StatusRecruiting
StartedJune 12, 2025
Main results expectedMarch 31, 2028
Study endsAugust 30, 2028
Registry record updatedJune 11, 2026
Trial IDNCT06409975 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal participants are English-speaking transgender or nonbinary young adults with reliable internet access who can commit to weekly live virtual sessions and do not have extensive prior mindfulness training or high current suicide risk or very severe depressive symptoms.

Probably not a fit

People with recent severe physical health crises, recent head trauma or seizures, high trauma symptom scores, PHQ-8 scores indicating moderately severe depression or higher, high suicide risk, or those already practicing mindfulness regularly are unlikely to benefit from this feasibility program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-arm feasibility project delivers an 8-week Mindful Self-Compassion (MSC) program remotely to transgender and nonbinary young adults via weekly 2.5-hour virtual classes and a 4-hour virtual retreat. Participants are asked to practice guided activities 20–30 minutes daily and complete surveys before, mid-way, after the program, and three months later. The team will track recruitment, attendance, adherence, dropout reasons, and patterns of missing data across five consecutive groups to determine whether the program and data-collection plan are workable. Investigators will also examine whether MSC activities need tailoring to improve usability and engagement for transgender and nonbinary young adults.

Why it matters

Potential benefit: If successful, the program could provide an accessible online way for transgender and nonbinary young adults to build self-compassion and coping skills.

How similar studies have gone: Mindful Self-Compassion programs have shown benefits for self-compassion and mental health in general and clinical populations, but they have been minimally tested specifically in transgender and nonbinary young adults.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* transgender, nonbinary, genderqueer (or another non-cisgender identity)
* have reliable access to a smart phone or computer/tablet and the Internet and is reasonably able to make the time commitment required of the program (self-report)
* speak and understand English

Exclusion Criteria:

* has had formal mindfulness training (i.e. mindfulness-based stress reduction course) or engages in regular mindfulness practice (15 minutes more than twice a week for the last six months or more)
* Score 15 or higher on the patient health questionnaire-8 (PHQ-8)
* Score 2 or higher on the Columbia Suicide Severity Rating Scale
* Experienced an acute physical health crisis (e.g., chemotherapy, recovery from severe injury) (Germer \& Neff, 2019, p. 80) in the past year
* Head trauma, seizure, or loss of consciousness in the past 6 months
* Reports a history of trauma AND Scores 14 or higher on Post-Traumatic Checklist, 6-item Civilian version
* Reports a diagnosis of a personality disorder
* Reports a diagnosis of schizophrenia or a history of psychosis
* Reports acute panic attack in the past month and history of acute panic attacks with concern/worry about having another one in the future OR Reports severe social anxiety which would make attending class too difficult
* Reports an acute episode of psychosis or suicide attempt in the past 12 months
* Has engaged in non-suicidal self-injury in the past 6 months
* Currently prescribed antipsychotic medications, benzodiazepine (equivalent to 30mg diazepam/day) or opioids (\>40mg morphine equivalent/day)
* Prescribed any other psychiatric medication, including medication for opioid use disorder, whose dose has been changed in the past 8 weeks or is anticipated to change in the next 2 months.
* Currently engage in harmful drinking (5 or more drinks on one occasion (Flentje et al., 2020) more than once in the past 2 weeks; OR have any concerns about the expectation to not be using substances during group sessions
* has undergone detoxification from alcohol or other drugs and has been in sustained remission (with or without medication) for less than 1 year
* Has been hospitalized overnight for mental health related reasons in the past year (any diagnoses except bipolar disorder) OR have a diagnosis of bipolar disorder and have had an episode of mania or have been hospitalized in the past 2 years
* Reports any other acute physical or mental illness symptoms that may make group participation difficult

Where it's running

  • N/A-- All study activities being conducted virtually
    Providence, Rhode Island, United States
    Recruiting

Study contacts

  • Principal investigator: Jordon D Bosse, PhD — University of Rhode Island
  • Study coordinator: Jordon D Bosse, PhD, RN
  • Email: jordon.bosse@uri.edu
  • Phone: 401-874-5313

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.