Minder sub‑scalp EEG to improve diagnosis and care for epilepsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares continuous sub‑scalp EEG monitoring with the Minder System to standard of care for people with drug‑resistant epilepsy whose seizures are not well captured by routine EEG. Participants either opt for implantation of the Minder device or continue with standard care; those who receive the implant are then randomized so their treating physician either has access to the continuously recorded EEG data or does not. The Minder System is FDA De Novo–classified and records continuous EEG from under the scalp to capture seizures that short‑term EEGs can miss. Outcomes focus on whether the device provides more reliable seizure data that can inform long‑term management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of focal and/or generalized epilepsy.
* Drug-resistant
* At least an average of 1 seizure within the past 3 months
* Participant completed a multi-day EEG assessment that was inconclusive, and is unchanged since the last EEG monitoring.

Exclusion Criteria:

* Epilepsy surgery within the past 6 months
* Active Deep Brain Stimulation (DBS) or Responsive Neurostimulator System (RNS)
* Participant needs treatments or assessments that are not indicated with the Minder System like Magnetic Resonance Imaging (MRI), Electro-Convulsive Therapy (ECT), lithrotripsy, and diathermy
* Participant cannot have surgery to have the device implanted

Where it's running

• UAB Epilepsy Center
  Birmingham, Alabama, United States Recruiting
• Mayo Clinic - Arizona
  Phoenix, Arizona, United States Recruiting
• University of California, Irvine Medical Center
  Irvine, California, United States Recruiting
• Stanford
  Palo Alto, California, United States Recruiting
• UC San Diego Health
  San Diego, California, United States Recruiting
• Yale School of Medicine
  New Haven, Connecticut, United States Recruiting

Study contacts

• Study coordinator: Epiminder, Director of Clinical Trials
• Email: clinical@epiminder.com
• Phone: 800-717-3185

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy

  This study tests whether low intensity focused ultrasound can help reduce seizures in adults with drug‑resistant epilepsy.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07680842

• Long-term follow-up of the Minder implanted EEG system for epilepsy care

  This follow-up will see if long-term use of the implanted Minder sub‑scalp EEG system helps doctors manage care for people with epilepsy whose seizures are not well captured by standard EEGs.

  Recruiting at 20 sites Epiminder America, Inc. · Birmingham, Alabama and 20 other locations · NCT07110454

• RAP-219 long-acting injectable safety and PK study in healthy adults

  This early study tests RAP-219-LAI in healthy adults to see how it behaves in the body and whether it is safe and tolerable.

  Recruiting Phase 1 Rapport Therapeutics Inc. · Adelaide · NCT07923097

• Why People with Epilepsy Get More Infections

  This study tests whether anti-seizure medicines affect immune function and infection risk in people with epilepsy.

  Recruiting University of Aberdeen · Aberdeen · NCT07903168

• Long-Term Epilepsy Outcomes in Children After Perinatal Stroke

  This study looks at how epilepsy progresses in kids who had a stroke before 28 days old to see how their seizures and syndromes evolve over time.

  Recruiting University Hospital, Strasbourg, France · Strasbourg · NCT07898397

• Hypothalamus structure and heart autonomic changes in drug-resistant epilepsy

  This study tests whether structural changes in the hypothalamus relate to cardiac autonomic dysfunction in adults with drug-resistant epilepsy.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens, Picardie · NCT07888543

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.