microRepair ABX mousse versus 0.20% chlorhexidine for healing after tooth extraction
Official title: Evaluation of Healing in Post-Extraction Sockets Using microRepair Abx Mousse Mouthwash Versus 0.20% Chlorhexidine
Run by University of Roma La Sapienza · NCT07555366 · Data updated 2026-11-12
This trial will test whether a biomimetic microRepair ABX mousse or a 0.20% chlorhexidine mouthwash helps adults 18–75 heal faster and with less pain after tooth extraction for endodontic or periodontal problems.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Roma La Sapienza Academic / other |
| Locations | 1 site (Roma, RM) |
| Status | Recruiting |
| Started | September 1, 2024 |
| Main results expected | November 1, 2026 |
| Study ends | March 1, 2027 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT07555366 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–75 who require tooth extraction for destructive caries, untreatable endodontic or periapical lesions, advanced periodontal disease, traumatic root fractures, malpositioned teeth, or non-restorable residual roots.
✕Probably not a fit
Patients who are under 18 or over 75, pregnant or breastfeeding, immunocompromised, have severe psychiatric disorders, substance abuse, or smoke more than 10 cigarettes per day are excluded and would not be expected to receive benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults scheduled for tooth extraction because of endodontic or periodontal issues are randomized to receive either a microRepair ABX mousse applied at home or a 0.20% chlorhexidine mouthwash. Clinical assessments occur at baseline and at 24 hours, 7 days, and 15 days post‑extraction, recording pain, swelling, odor, pigmentation, and plaque on the surgical wound. Wound healing is quantified using the Clinical Healing Index that assesses redness, edema, bleeding, suppuration, granulation tissue, epithelialization, and pain on palpation, while patient-reported outcomes include VAS pain scores and OHIP-14. The study also records patient satisfaction and product pleasantness and monitors adverse events during home application.
Why it matters
Potential benefit: If successful, the microRepair ABX mousse could speed tissue regeneration and reduce post‑operative pain and complications compared with standard chlorhexidine.
How similar studies have gone: Chlorhexidine is an established standard for reducing oral microbial load and preventing complications, while biomimetic microparticle products like microRepair ABX have limited clinical evidence for post‑extraction wound regeneration and remain relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Age range: Patients between 18 and 75 years of age. Indication for tooth extraction: Specifically for cases involving: * Destructive caries that do not allow for conservative or prosthetic recovery. * Untreatable endodontic and/or periapical lesions. * Advanced periodontal lesions with significant loss of supporting tissue. * Traumatic lesions involving root fractures (vertical or at the middle third). * Malpositioned teeth causing functional alterations. * Roots that cannot be prosthetically recovered or residual roots. Exclusion Criteria: Age: Patients under 18 or over 75 years of age. Systemic Conditions: Presence of immunodepression or immunocompromisation (e.g., HIV infection). Pregnancy and Lactation: Women who are currently pregnant or breastfeeding. Mental Health: Presence of psychiatric disorders. Tobacco Use: Severe smokers, defined as consuming more than 10 cigarettes per day. Substance Abuse: History of alcohol or drug abuse.
Where it's running
-
Sapienza università di Roma
Roma, Rm, Italy Recruiting
Study contacts
- Study coordinator: Fabrizio Guerra
- Email: fabrizio.guerra@uniroma1.it
- Phone: 3283150627
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.