Microneedling with platelet-rich plasma versus microneedling alone for reducing gum (gingival) pigmentation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults with anterior gingival melanin pigmentation receive preoperative ultrasonic scaling and oral hygiene instruction and are randomly assigned to two groups. Both groups receive local infiltration anesthesia and microneedling of the pigmented gingiva with a Dermapen device until mild microbleeding is seen, with clinical photographs taken at baseline, 1 month, and 6 months. The intervention group additionally receives injections of autologous PRP prepared from 10 mL of the patient’s blood, while the control group has microneedling alone. Outcomes compare pigment intensity reduction and clinical appearance over a 6-month follow-up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* • Patients exhibiting melanin hyperpigmentation in the anterior region of the upper or lower gingiva.

  * Age ≥ 18 year old.
  * Patients should be free from any systemic diseases according to modified Cornell Medical index (Abramson 1966).
  * Non- smokers

Exclusion Criteria:

* • Fully edentulous patients.

  * Patients with endocrine disorders causing hyperpigmentation or drug induced gingival pigmentation. (Sreeja, Ramakrishnan et al. 2015)
  * Pregnant or lactating females.

Where it's running

• Cairo university
  Cairo, El Manial, Egypt Recruiting
• Faculity of Dentistry, Cairo university
  Cairo, El Manyl, Egypt Recruiting
• Faculity of Dentistry, Cairo university
  Cairo, El Manyl, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.