Metformin before surgery and risk of nausea and vomiting after anesthesia.

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational cohort of 909 adults having surgery under general anesthesia with endotracheal intubation at the Sixth Affiliated Hospital of Sun Yat-sen University. Participants already on metformin (n=303) will be compared with those not taking metformin (n=606) using structured postoperative surveys. The primary outcome is the incidence of postoperative nausea and vomiting (PONV) within 0–120 hours after surgery, and secondary outcomes include interval-specific incidence and severity, antiemetic use, and quality of recovery measured by the QoR-15. Data will be collected prospectively without altering routine perioperative care.

Why it matters

Who can join: the full rules

Inclusion criteria

1. Voluntarily sign the informed consent form;
2. Age ≥ 18 years;
3. Patients who require surgical treatment under endotracheal intubation with general anesthesia as determined by the treating physician.

Exclusion criteria

1. Emergency surgery;
2. Currently taking medications with established antiemetic effects (e.g., corticosteroids, antipsychotics) due to underlying medical conditions;
3. Cognitive impairment or psychiatric disorders that preclude cooperation with questionnaire assessments;
4. Anticipated inability to extubate the tracheal tube postoperatively, which would interfere with outcome assessment;
5. Presence of nausea and/or vomiting prior to surgery.

Where it's running

• The Sixth Affiliated Hospital, Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Yang Zhao, Dr — Sixth Affiliated Hospital, Sun Yat-sen University
• Study coordinator: Yang Zhao, Doctor
• Email: zhaoy47@mail.sysu.edu.cn
• Phone: 0086-02038254070

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.