Metformin added to levodopa/carbidopa for Parkinson's disease
Official title: Safety and Efficacy of Metformin in Patients With Parkinson Disaese
Run by Tanta University · NCT07229651 · Data updated 2026-11-12
This will test whether adding metformin to levodopa/carbidopa helps people aged 50 and older with Parkinson's disease.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Ages | 50 Years to 70 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Tanta) |
| Status | Recruiting |
| Started | November 10, 2025 |
| Main results expected | November 20, 2026 |
| Study ends | September 20, 2027 |
| Registry record updated | November 21, 2025 |
| Trial ID | NCT07229651 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 50 or older with a confirmed diagnosis of Parkinson's disease who are currently treated with levodopa/carbidopa and meet the trial's safety criteria.
✕Probably not a fit
Patients with atypical or secondary parkinsonism, active cancer, significant cardiovascular or coagulation disorders, pregnancy or lactation, current use of excluded medications, or substance addiction are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are adults aged 50 and older with confirmed Parkinson's disease who are already taking levodopa/carbidopa. In this interventional Phase 2/3 protocol, metformin is given in addition to standard levodopa/carbidopa therapy to observe effects on motor symptoms and monitor safety. Key exclusions include secondary or atypical parkinsonism, recent stereotaxic surgery, active malignancy, significant cardiovascular or coagulation disorders, pregnancy or lactation, substance addiction, and concurrent anti-inflammatory drug use. Safety assessments and symptom monitoring are conducted through scheduled clinic visits at the trial site.
Why it matters
Potential benefit: If successful, adding metformin could improve symptom control or slow disease progression for some patients with Parkinson's disease.
How similar studies have gone: Preclinical studies and some observational data suggest metformin may have neuroprotective effects, but randomized clinical evidence in Parkinson's disease is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Eligible participants were men and women aged 50 years or older with a confirmed diagnosis of PD Patients receiving levodopa/carbidopa therapy. Exclusion Criteria: Secondary causes of parkinsonism Patients taking anti-inflammatory drugs Atypical parkinsonian syndromes Prior stereotaxic surgery for Parkinson's disease Pregnancy and lactation Cardiovascular disease patients Patients with coagulation disorders Suffering from active malignancy Addiction to alcohol and / or drugs Known allergy to the studied medications
Where it's running
-
Tanta University
Tanta, Egypt Recruiting
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions
A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.
-
Tributyrin for PSP: a virtual, early-phase study
This study tests whether tributyrin is safe and tolerable in people with Progressive Supranuclear Palsy who are 45 or older, using virtual visits.
-
A look at why Lewy body conditions cause visual hallucinations
This study tests brain‑imaging in people with Lewy body diseases who do or don’t experience visual hallucinations, and in healthy volunteers, to see how brain networks might create these images.
-
How physical activity might help people with Parkinson’s disease who have DBS-STN implants
This study tests whether adding regular physical activity can help people with Parkinson’s who have DBS-STN stimulation by trying a structured physiotherapy approach alongside standard care.
-
Can hippotherapy improve mobility, gait, balance, and quality of life in people with Parkinson's disease?
This pilot trial tests whether adding horse-assisted therapy to standard rehab helps mobility, gait, balance, and perceived health in adults with Parkinson's disease.
-
Gut methane and Parkinson's: measuring if a probiotic helps people with Parkinson's, REM sleep behavior disorder, or cognitive concerns
This study tests whether a probiotic containing Limosilactobacillus reuteri can help people with Parkinson's disease, those at high risk for PD, and related cognitive issues by potentially improving gut methane levels and overall symptoms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.