Metabolic effects of exercise and diet in women with endometrial cancer preparing for staging surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional program enrolls adult women with histologically confirmed endometrioid endometrial cancer who are candidates for staging surgery and able to attend supervised exercise sessions. Participants follow a structured physical activity regimen plus a nutritional algorithm prior to surgery, with monitoring of muscle mass and strength, metabolic and inflammatory blood markers, and patient-reported quality of life. Body composition may be evaluated using available CT imaging and functional tests, and safety is screened by ECG and standard labs. The intervention is delivered at the National Institute of Cancerología in Mexico City and compares pre- and post-intervention measures to see if the combined approach improves surgical readiness and metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. -Ability to understand the nature of the study and provide written informed consent.
2. -Women aged over 18 and under 65 years.
3. -Availability to attend exercise sessions.
4. -Willingness and ability to comply with scheduled visits, the proposed nutritional algorithm, treatment plan, and laboratory tests.
5. -Histologically confirmed diagnosis of endometrioid-type endometrial cancer by biopsy.
6. -Normal electrocardiogram (ECG) result.
7. -No prior oncological treatment.
8. -Body mass index (BMI) greater than 20 kg/m².
9. -Availability of a computed tomography (CT) scan.
10. -Candidates for staging surgery.

Exclusion Criteria:

1. -Patients with advanced clinical stage or stage IVB disease (according to FIGO 2018 criteria).
2. -Patients with a prior or concurrent malignancy, except non-melanoma skin cancer.
3. -Patients with uncontrolled systemic arterial hypertension.
4. -Patients with renal dysfunction (eGFR ≤ 60 mL/min/1.73 m²).
5. -Patients with uncontrolled psychiatric disorders, including claustrophobia.
6. -Patients with concurrent infections.
7. -Patients with autoimmune disease.
8. -Patients with neuromuscular disease.
9. -Contraindications to physical exercise.
10. -Vulnerable situations (e.g., homelessness preventing adherence to diet, or incarceration).

Where it's running

• Instituto Nacional de Cancerología
  México, Tlalpan, Mexico Recruiting

Study contacts

• Principal investigator: Denisse Castro Eguiluz, PhD — Ministry of Science, Humanities and Technology (SECIHTI)-National Cancer Institute.
• Study coordinator: Denisse Castro Eguiluz, PhD
• Email: adcastro@secihti.mx
• Phone: +52 55 4194 0650

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.