Menstrual phase, anesthetic use, and postoperative nausea after gallbladder removal
Official title: Impact of Menstrual Phases and Menopause on Intraoperative Anesthetic Consumption and Postoperative Nausea and Vomiting: A Prospective Observational Study
Run by Ankara Etlik City Hospital · NCT07456202 · Data updated 2026-11-12
We will see if menstrual phase affects how much anesthetic women need and their chance of nausea and vomiting after elective laparoscopic gallbladder removal.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 120 (estimated) |
| Sponsor | Ankara Etlik City Hospital Government |
| Locations | 1 site (Ankara, Ankara) |
| Status | Recruiting |
| Started | March 7, 2026 |
| Main results expected | August 15, 2026 |
| Study ends | August 16, 2026 |
| Registry record updated | July 13, 2026 |
| Trial ID | NCT07456202 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adult women aged 18–65 with ASA physical status I–III scheduled for elective laparoscopic cholecystectomy who are not using hormonal contraception or replacement and can provide informed consent.
✕Probably not a fit
Men, people outside the 18–65 age range, those on hormonal therapies, with emergency or converted/open cholecystectomy, or with ASA ≥IV or severe comorbidities are unlikely to benefit from this study's findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational cohort of women undergoing elective laparoscopic cholecystectomy under general anesthesia. Postoperative serum progesterone will be used to determine menstrual phase, intraoperative anesthetic drug consumption will be recorded quantitatively, and early postoperative nausea and vomiting will be measured with validated scoring tools. No interventions beyond standard clinical care will be applied. The study compares anesthetic requirements and PONV incidence and severity across menstrual phases.
Why it matters
Potential benefit: If a relationship is identified, anesthesia dosing and anti-nausea strategies could be better tailored to menstrual phase to reduce anesthetic exposure or PONV.
How similar studies have gone: Prior small observational studies have reported mixed results, with some suggesting menstrual phase can alter anesthetic sensitivity and PONV risk but evidence remains limited and inconsistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 65 years * American Society of Anesthesiologists (ASA) physical status I-II-III * Scheduled for elective laparoscopic cholecystectomy under general anesthesia * Willing and able to provide written informed consent Exclusion Criteria: * Age outside the specified range (younger than 18 or older than 65 years) * Male patients * American Society of Anesthesiologists (ASA) physical status ≥ IV * Severe systemic comorbidities (e.g., significant cardiovascular, hepatic, renal, or pulmonary disease) * Conversion from laparoscopic to open cholecystectomy * History of alcohol, drug, or substance abuse * Visual or hearing impairment interfering with study assessments * Current hormone replacement therapy * Use of oral contraceptives * Preoperative nausea or vomiting * History of severe postoperative nausea and vomiting * Neurological or psychiatric disorders affecting assessment reliability * Hemodynamic instability during surgery * Postoperative admission to intensive care unit * Acute cholecystitis at the time of surgery * Refusal to participate or inability to provide informed consent
Where it's running
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Ankara Etlik City Hospital
Ankara, Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: oya çimen, Specialist in Anesthesiology — Ankara Etlik City Hospital
- Study coordinator: oya Çimen, Specialist in Anesthesiology
- Email: oya.cimen@hotmail.com
- Phone: +905334494750
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.