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Clinical trial Recruiting at 1 site Interventional Ages 65 and up

Memory boost in aging with tailored brain stimulation

Official title: Personalized Memory Enhancement in Aging: Pattern-Optimized tACS With Closed-Loop Precision Modulation

Run by Boston University Charles River Campus · NCT07461584 · Data updated 2026-11-12

This study tests whether personalized high-resolution tACS can improve memory in healthy older adults by adjusting stimulation patterns and schedules.

Quick facts

Study typeInterventional
Ages65 Years and up
SexAll
Enrollment240 (estimated)
SponsorBoston University Charles River Campus
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedJune 1, 2026
Main results expectedJanuary 31, 2031
Study endsJanuary 31, 2031
Registry record updatedJuly 22, 2026
Trial IDNCT07461584 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 65 and older without dementia or major neurological conditions who meet vision and safety criteria.

Probably not a fit

Individuals with significant cognitive impairment, certain implants, or conditions that contraindicate brain stimulation may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use multimodal imaging to guide individualized high-resolution tACS aimed at strengthening memory networks in aging adults. The study compares patterned versus continuous stimulation over 1, 3, or 5 consecutive days to see how durability of effects varies. By tracking frontotemporal neural synchrony related to memory processes, the project seeks to optimize when and how long stimulation can help memory in non-demented seniors.

Why it matters

Potential benefit: If successful, participants may experience lasting improvements in memory and a non-drug approach to supporting cognitive health in aging.

How similar studies have gone: Preliminary data suggest that personalized and adaptive brain stimulation can be feasible and may enhance memory, but larger studies are needed for confirmation.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* 65 years of age or older
* normal or corrected-to-normal vision
* color vision

Exclusion Criteria:

* pregnant
* metal implants in head
* implanted electronic devices
* history of neurological problems or head injury
* skin sensitivity
* claustrophobia
* dementia (normal Montreal Cognitive Assessment \> 25)
* depression (normal Geriatric Depression Scale \< 10)
* history of psychosis
* cognitive deficits (MoCA\>25)
* any psychoactive medication

Where it's running

  • 111 Cummington Mall
    Boston, Massachusetts, United States     Recruiting

Study contacts

  • Principal investigator: Robert Reinhart, PhD — Boston University Charles River Campus
  • Study coordinator: Robert Reinhart, PhD
  • Email: rmgr@bu.edu
  • Phone: (617) 353-9481

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.